Synthesis and biological activity of potential antiviral compounds through 1,3-dipolar cycloadditions; Part 1: general aspects and reactions of azides

Prominent in the current stage of drug development, antiviral compounds can be efficiently prepared through cycloaddition reactions. This review reports the use of 1,3-dipolar cycloaddition reactions of selected 1,3dipoles, in particular azides, in the light of their application for the preparation of key intermediates in the design and synthesis of compounds that were tested for their antiviral activities against a variety of viruses. The products obtained from these pericyclic reaction approaches were tested for their activities in terms of blocking the virus replication and the relevant biological data are highlighted.

Automated summary

This review discusses the use of 1,3-dipolar cycloaddition reactions, particularly with azides, in the preparation of key intermediates for the design and synthesis of antiviral compounds. The resulting products were tested for their ability to block virus replication, and the relevant biological data are emphasized.