Journal
CHEMICAL SOCIETY REVIEWS
Volume 51, Issue 21, Pages 9127-9173Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cs00618a
Keywords
-
Categories
Funding
- National Institutes of Health [1R01EB023052-01A1, 1R01HL140618-01]
Ask authors/readers for more resources
This review provides a biomacromolecular design roadmap for the development of tough adhesive surgical sealants. The intrinsic toughness and elasticity of polymers are achieved through the introduction of strong and dynamic inter- and intramolecular interactions, either through polymer chain design or the use of crosslink regulating additives. Efforts have also been made to promote underwater adhesion through covalent/noncovalent bonds and micro/macro-interlock mechanisms. The measurement and reporting requirements for fair comparisons of different materials and their properties are discussed.
Emerging sutureless wound-closure techniques have led to paradigm shifts in wound management. State-of-the-art biomaterials offer biocompatible and biodegradable platforms enabling high cohesion (toughness) and adhesion for rapid bleeding control as well as robust attachment of implantable devices. Tough bioadhesion stems from the synergistic contributions of cohesive and adhesive interactions. This Review provides a biomacromolecular design roadmap for the development of tough adhesive surgical sealants. We discuss a library of materials and methods to introduce toughness and adhesion to biomaterials. Intrinsically tough and elastic polymers are leveraged primarily by introducing strong but dynamic inter- and intramolecular interactions either through polymer chain design or using crosslink regulating additives. In addition, many efforts have been made to promote underwater adhesion via covalent/noncovalent bonds, or through micro/macro-interlock mechanisms at the tissue interfaces. The materials settings and functional additives for this purpose and the related characterization methods are reviewed. Measurements and reporting needs for fair comparisons of different materials and their properties are discussed. Finally, future directions and further research opportunities for developing tough bioadhesive surgical sealants are highlighted.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available