Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 9, Issue 22, Pages 6142-6148Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2qo01312f
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Funding
- National Natural Science Foundation of China [22002067, 22202228]
- Hundred-Talent Program of CAS
- Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province [20220052]
- Science and Technology Project of Shanxi Province [202103021223457]
- State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, CAS [2021BWZ011]
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A new method for synthesizing various formamides has been developed, which does not require harsh reaction conditions and can yield high amounts of products. This is of great importance for the synthesis of gram-scale aromatic and aliphatic amides.
Current methods for preparing formamides are limited by the narrow substrate scope and requirement for harsh reaction conditions. A base-mediated formamidation of amines with CO (<2 bar) under mild conditions was developed, which enabled the synthesis of a wide range of formamides in 61% to 98% yields under transition-metal-free conditions. This provides a useful strategy for generating gram amounts of various aromatic and aliphatic amides.
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