Polyphenols as Tyrosine Kinase Inhibitors for the Treatment of Metastatic Cancers: Current and Future Perspective

Cancer is the leading cause of death worldwide. The increased cancer mortality rate is due to metastasis, which is a key stumbling block in cancer treatment. Polyphenols are a broad group of antioxidant-rich natural chemicals that are frequently utilized as chemopreventives and adjuvants in cancer treatments. The tyrosine kinase pathway is one of many signaling pathways involved in the metastatic cascade. Tyrosine kinases are a class of enzymes that play a role in cancer progression. Despite a huge body of studies confirming their antimetastatic effects, polyphenols' significance in cancer metastasis remains underappreciated. To discover publications that emphasize the topic of this review study, a thorough literature search was undertaken in several electronic databases. PubMed Central, Google Scholar, Scopus, and Medline were among them. As a result, the current analysis outlines cancer metastasis signaling pathways, emphasizing the role of tyrosine kinases in the process. Polyphenols can decrease tyrosine kinase activity, which adds to their antimetastatic properties. This review also emphasizes the role of polyphenols in preventing cancer metastasis by interfering with the tyrosine kinase signaling cascade, which could lead to the development of future antimetastatic medications.

Automated summary

Cancer is the leading cause of death globally, and metastasis is a major obstacle in cancer treatment. Polyphenols, natural chemical compounds with antioxidant properties, are commonly used in cancer prevention and adjuvant therapies. The tyrosine kinase pathway plays a role in the metastatic cascade, and polyphenols can decrease tyrosine kinase activity to inhibit metastasis.