Journal
KOREAN CIRCULATION JOURNAL
Volume 46, Issue 5, Pages 719-726Publisher
KOREAN SOC CARDIOLOGY
DOI: 10.4070/kcj.2016.46.5.719
Keywords
Respiratory syncytial virus; Congenital heart disease; Pediatrics; Palivizumab; Prophylaxis
Categories
Funding
- Korean Pediatric Cardiology Society
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Background and Objectives: We conducted a review of current data on respiratory syncytial virus (RSV) prophylaxis with palivizumab, in Korean children with congenital heart diseases (CHD). In 2009, the Korean guideline for RSV prophylaxis had established up to five shots monthly per RSV season, only for children <1 year of age with hemodynamic significance CHD (HS-CHD). Subjects and Methods: During the RSV seasons in 2009-2015, we performed a retrospective review of data for 466 infants with CHD, examined at six centers in Korea Results: Infants received an average of 3.7 +/- 1.9 (range, 1-10) injections during the RSV season. Fifty-seven HS-CHD patients (12.2%) were hospitalized with breakthrough RSV bronchiolitis, with a recurrence in three patients, one year after the initial check-up. Among patients with simple CHD, only five (1.1%) patients received one additional dose postoperatively, as per the limitations set by the Korean guideline. Among the 30 deaths (6.4%), five (1.1%) were attributed to RSV infection; three to simple CHD, one to Tetralogy of Fallot, and one to hypertrophic cardiomyopathy (HCM). Of the three HCM patients that exceeded guidelines for RSV prophylaxis, two (66.6%) were hospitalized, and one died of RSV infection (33.3%). Conclusion: In accordance to the Korean guideline, minimal injections of palivizumab were administered to patients having HS-CHD
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