4.6 Article

The immune cell atlas of human neuroblastoma

Related references

Note: Only part of the references are listed.
Article Oncology

Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment

Youmna Kfoury et al.

Summary: Bone metastases are devastating complications of cancer, particularly common in prostate cancer and refractory to immunotherapy. Analysis of single cells reveals multifaceted immune distortion in metastatic prostate cancer, with overexpression of CCL20 by myeloid cells and appearance of unique macrophages specific to PCa bone metastases. Disruption of the CCL20-CCR6 axis restores T cell reactivity and prolongs animal survival in mice with syngeneic PCa bone metastases, suggesting a targeted approach for relieving local immunosuppression.

CANCER CELL (2021)

Article Multidisciplinary Sciences

Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype

Evelyn S. Hanemaaijer et al.

Summary: Neuroblastoma, the most common extracranial solid tumor in children, is believed to originate from the neural crest and primarily occurs in the adrenal gland. A study on the developing mouse adrenal gland identified five main cell cluster groups, including Schwann cell precursor and neuroblast clusters. The signature of medullary SCP cluster was found to correlate with disease phenotype in neuroblastoma patients, with a high score associated with better overall survival rates.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Biochemistry & Molecular Biology

Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis

Nathan D. Mathewson et al.

Summary: This study utilized single-cell RNA sequencing to uncover the gene expression and clonal landscape of T cells in diffuse gliomas, identifying potential effectors of anti-tumor immunity. The research revealed that KLRB1 and its associated transcriptional program play an inhibitory role in tumor immunity, and blocking its function enhances T cell killing of glioma cells.
Article Oncology

Long-Term Follow-up of a Phase III Study of ch14.18 (Dinutuximab) plus Cytokine Immunotherapy in Children with High-Risk Neuroblastoma: COG Study ANBL0032

Alice L. Yu et al.

Summary: The study showed that immuotherapy with dinutuximab improved outcomes for high-risk neuroblastoma patients. Although early termination for efficacy resulted in a smaller sample size, clinically significant long-term survival differences were observed.

CLINICAL CANCER RESEARCH (2021)

Review Oncology

The immune landscape of neuroblastoma: Challenges and opportunities for novel therapeutic strategies in pediatric oncology

Judith Wienke et al.

Summary: Immunotherapy shows promise in treating pediatric cancers, but faces challenges in pediatric oncology such as low treatment success rates and tumor immune evasion strategies.

EUROPEAN JOURNAL OF CANCER (2021)

Article Multidisciplinary Sciences

Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs

Mark Yarmarkovich et al.

Summary: The majority of oncogenic drivers are intracellular proteins, thus limiting immunotherapeutic targeting. However, targeting non-immunogenic intracellular oncoproteins like PHOX2B using peptide-centric CARs shows promise in expanding immunotherapeutic targets and potentially benefiting a wider range of patients by breaking conventional HLA restriction.

NATURE (2021)

Article Multidisciplinary Sciences

Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell

Gerda Kildisiute et al.

Summary: The neuroblastoma cancer cells resemble fetal sympathoblasts, indicating a pan-neuroblastoma cancer cell state that could potentially be targeted for novel treatment strategies. The findings highlight the importance of understanding the phenotype of neuroblastoma cells for the development of immunotherapeutic and targeted avenues.

SCIENCE ADVANCES (2021)

Article Immunology

Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics

Hamish W. King et al.

Summary: Our study provides a comprehensive roadmap of human B cell maturation by analyzing single-cell transcriptomics and antibody repertoires, revealing the heterogeneity of memory B cells with diverse functional and signaling states. We reconstruct gene expression dynamics during B cell activation, showing a pre-germinal center state prepared for class switch recombination, and dissect how antibody class-dependent gene expression in germinal center and memory B cells is linked with potential fate and function influence. Our analyses uncover the dynamic cellular states that shape human B cell-mediated immunity, emphasizing the potential role of antibody isotype during antibody-based selection.

SCIENCE IMMUNOLOGY (2021)

Article Oncology

Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy

Chirag Krishna et al.

Summary: Clear cell renal cell carcinomas (ccRCCs) are highly immune infiltrated, and this study investigates the immune landscape of ccRCC using paired single-cell RNA (scRNA) and T cell receptor (TCR) sequencing, revealing extensive heterogeneity within and between patients. The study shows that tissue-resident T cells and tumor-associated macrophages (TAMs) are associated with responses to immune checkpoint blockade (ICB) and targeted therapies, highlighting the importance of cellular programs in therapeutic efficacy for ccRCC.

CANCER CELL (2021)

Article Oncology

NTRK1/TrkA Signaling in Neuroblastoma Cells Induces Nuclear Reorganization and Intra-Nuclear Aggregation of Lamin A/C

Lukas Funke et al.

Summary: This study provides insight into the proteomic and phosphoproteomic dynamics induced by NTRK1 signaling. Activation of NTRK1 leads to upregulation and phosphorylation of Lamin A/C, with aggregation within nucleic foci, regardless of the MYCN status in neuroblastoma cells.

CANCERS (2021)

Article Genetics & Heredity

Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin

Polina Kameneva et al.

Summary: Single-cell transcriptome profiling of human embryonic sympathoadrenal tissues reveals developmental transitions and suggests that intra-adrenal sympathoblasts from Schwann cell precursors may be potential neuroblastoma cell origins. The majority of extra-adrenal sympathoblasts appear to arise from migratory neural crest cells, while intra-adrenal sympathoblasts seem to be directly derived from nerve-associated Schwann cell precursors. This process persists during several weeks of development within the large intra-adrenal ganglia-like structures, potentially serving as reservoirs of originating cells in neuroblastoma.

NATURE GENETICS (2021)

Article Genetics & Heredity

Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma

Selina Jansky et al.

Summary: Single-cell transcriptomic analysis reveals cell types and lineage trajectories during different developmental stages in neuroblastomas and healthy adrenal glands. The transcriptomes of neuroblastoma cells closely resemble developing neuroblasts of the adrenal gland.

NATURE GENETICS (2021)

Article Neurosciences

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

Ana Rita Pombo Antunes et al.

Summary: By utilizing single-cell RNA sequencing and CITE-seq, this study reveals the complexity of the immune landscape in glioblastomas, including conserved populations of dendritic cells and macrophages. The results indicate that microglia-derived tumor-associated macrophages dominate in newly diagnosed tumors, but are replaced by monocyte-derived TAMs in recurrences.

NATURE NEUROSCIENCE (2021)

Review Oncology

Combined Effects of Myeloid Cells in the Neuroblastoma Tumor Microenvironment

Jennifer Frosch et al.

Summary: Neuroblastoma, a childhood solid cancer, is characterized by resistance to treatment and poor prognosis. Immunotherapeutic approaches targeting myeloid cells show potential, but clinical trials have not replicated preclinical results. Suppressive myeloid cells in the tumor microenvironment play a crucial role in inhibiting antitumor immune responses, correlating with aggressive disease, treatment resistance, and poor prognosis.

CANCERS (2021)

Article Oncology

Immune Monitoring during Therapy Reveals Activitory and Regulatory Immune Responses in High-Risk Neuroblastoma

Celina L. Szanto et al.

Summary: Neuroblastoma, a childhood cancer, has a poor prognosis despite intensive treatment including immunotherapy, with immune system's fighting capacity playing a crucial role. This study explores the dynamics of immune cell subsets during therapy in high-risk neuroblastoma patients, finding impairment in overall immune system fighting capacity and variations between patients. The study suggests the need for more specific immune-enhancing strategies to improve treatment outcomes.

CANCERS (2021)

Article Multidisciplinary Sciences

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors

O. C. Bedoya-Reina et al.

Summary: The study shows that childhood neuroblastoma can be separated into high and low risk groups with different cell identities and malignancy potential, indicating two distinct disease entities. Low-risk neuroblastoma resembles sympatho- and chromaffin cells in terms of transcriptome, while the malignant cells in high-risk neuroblastoma resemble a subtype of cholinergic progenitor population in human post-natal gland. The findings reveal different gene expression programs for worst and better survival in correlation with age at diagnosis, reflecting clinical heterogeneity and outcome of neuroblastoma tumors.

NATURE COMMUNICATIONS (2021)

Review Oncology

Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies

Hiroyoshi Nishikawa et al.

Summary: With the widespread use of immunotherapies in cancer treatment, understanding the immune landscape in the tumor microenvironment has become crucial. Regulatory T cells (Tregs) play a key role in cancer immunity but also contribute to immune evasion by tumor cells. Targeting Tregs is considered a crucial aspect of cancer immunotherapy, especially in tumors with abundant Treg presence.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Review Immunology

Transcriptional regulation of memory B cell differentiation

Brian J. Laidlaw et al.

Summary: Memory B cells play a critical role in developing protective immunity and efforts to induce broadly protective MBCs to rapidly mutating pathogens with vaccines have been unsuccessful. Understanding the signals and transcription factors regulating MBC development and function are crucial for overcoming challenges in vaccine development.

NATURE REVIEWS IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Tissue Determinants of Human NK Cell Development, Function, and Residence

Pranay Dogra et al.

Article Multidisciplinary Sciences

B cells are associated with survival and immunotherapy response in sarcoma

Florent Petitprez et al.

NATURE (2020)

Article Multidisciplinary Sciences

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

Rita Cabrita et al.

NATURE (2020)

Article Multidisciplinary Sciences

B cells and tertiary lymphoid structures promote immunotherapy response

Beth A. Helmink et al.

NATURE (2020)

Review Immunology

Influence of the Tumor Microenvironment on NK Cell Function in Solid Tumors

Ombretta Melaiu et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Immunology

NK Cell-Based Immune Checkpoint Inhibition

Muhammad Khan et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

Martina Molgora et al.

Article Immunology

Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome

Antony B. Holmes et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Article Multidisciplinary Sciences

A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response

Donghai Xiong et al.

NATURE COMMUNICATIONS (2020)

Review Cell Biology

Monocyte heterogeneity and functions in cancer

Claire E. Olingy et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

Review Neurosciences

Neuroblastoma - A Neural Crest Derived Embryonal Malignancy

John Inge Johnsen et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Article Multidisciplinary Sciences

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

Amira A. Barkal et al.

NATURE (2019)

Article Biochemical Research Methods

Joint analysis of heterogeneous single-cell RNA-seq dataset collections

Nikolas Barkas et al.

NATURE METHODS (2019)

Review Immunology

Location, location, location: Tissue resident memory T cells in mice and humans

Peter A. Szabo et al.

SCIENCE IMMUNOLOGY (2019)

Review Oncology

Immune checkpoint inhibitors of PD-L1 as cancer therapeutics

Akintunde Akinleye et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Article Multidisciplinary Sciences

Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease

Peter A. Szabo et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome

Chao Yang et al.

NATURE COMMUNICATIONS (2019)

Article Oncology

Advances in Anti-GD2 Immunotherapy for Treatment of High-risk Neuroblastoma

Julie Voeller et al.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY (2019)

Review Immunology

Macrophages as regulators of tumour immunity and immunotherapy

David G. DeNardo et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Article Pediatrics

Invariant natural killer T infiltration in neuroblastoma with favorable outcome

Tomoro Hishiki et al.

PEDIATRIC SURGERY INTERNATIONAL (2018)

Review Cell Biology

Myeloid cell heterogeneity in cancer: not a single cell alike

Mate Kiss et al.

CELLULAR IMMUNOLOGY (2018)

Article Medicine, Research & Experimental

PBMC fixation and processing for Chromium single-cell RNA sequencing

Jinguo Chen et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

Review Multidisciplinary Sciences

CAR T cell immunotherapy for human cancer

Carl H. June et al.

SCIENCE (2018)

Review Biotechnology & Applied Microbiology

Targeting macrophages: therapeutic approaches in cancer

Luca Cassetta et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Multidisciplinary Sciences

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

Alexandra-Chloe Villani et al.

SCIENCE (2017)

Article Multidisciplinary Sciences

RORγt and RORα signature genes in human Th17 cells

Glenda Castro et al.

PLOS ONE (2017)

Article Biochemistry & Molecular Biology

Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing

Chunhong Zheng et al.

Review Immunology

CD69: from activation marker to metabolic gatekeeper

Danay Cibrian et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2017)

Article Immunology

CD83 Modulates B Cell Activation and Germinal Center Responses

Lena Krzyzak et al.

JOURNAL OF IMMUNOLOGY (2016)

Review Oncology

Human memory B cells

M. Seifert et al.

LEUKEMIA (2016)

Review Immunology

FOXP3+ regulatory T cells and their functional regulation

Zhiyuan Li et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2015)

Review Oncology

Advances in Risk Classification and Treatment Strategies for Neuroblastoma

Navin R. Pinto et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

Review Oncology

Immune evasion in cancer: Mechanistic basis and therapeutic strategies

Dass S. Vinay et al.

SEMINARS IN CANCER BIOLOGY (2015)

Article Cell & Tissue Engineering

A distinct gene expression signature characterizes human neuroblastoma cancer stem cells

Robert A. Ross et al.

STEM CELL RESEARCH (2015)

Article Medicine, General & Internal

Chemokines and immunity

Diana Carolina Torres Palomino et al.

EINSTEIN-SAO PAULO (2015)

Review Immunology

Oncology Meets Immunology: The Cancer-Immunity Cycle

Daniel S. Chen et al.

IMMUNITY (2013)

Review Immunology

Innate and adaptive immune cells in the tumor microenvironment

Thomas F. Gajewski et al.

NATURE IMMUNOLOGY (2013)

Article Oncology

Clinical Significance of Tumor-Associated Inflammatory Cells in Metastatic Neuroblastoma

Shahab Asgharzadeh et al.

JOURNAL OF CLINICAL ONCOLOGY (2012)

Review Immunology

Chronic inflammation in cancer development

Gabriele Multhoff et al.

FRONTIERS IN IMMUNOLOGY (2012)

Review Immunology

Immunological aspects of cancer chemotherapy

Laurence Zitvogel et al.

NATURE REVIEWS IMMUNOLOGY (2008)

Review Immunology

Regulatory T cells, tumour immunity and immunotherapy

WP Zou

NATURE REVIEWS IMMUNOLOGY (2006)

Article Oncology

Notch signaling in neuroblastoma

S Påhlman et al.

SEMINARS IN CANCER BIOLOGY (2004)