Journal
JOURNAL OF THORACIC DISEASE
Volume 8, Issue 7, Pages 1772-1779Publisher
PIONEER BIOSCIENCE PUBL CO
DOI: 10.21037/jtd.2016.06.29
Keywords
MiR-361-5p; in situ hybridization(ISH); breast cancer (BC); prognosis
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Funding
- National Natural Science Foundation of China [81202079, 81201531]
- Shanghai Committee of Science and Technology Funds [11QA1401400, 12ZR1406200, 12DZ2260100, 12140901502]
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Background: MicroRNA-361-5p (miR-361-5p) has been reported to be tumor suppressor in colorectal, gastric and prostate cancer, but as an oncogene in cervical cancer. No previous research has focused on the expression of miR-361-5p and its exact prognostic role in breast cancer (BC). Methods: In this study, a tissue microarray (TMA)-based miRNA detection in situ hybridization (ISH) with LNA probe was used to detect miR-361-5p expression in 375 BC tissue. The expression level of miR-361-5p in BC and its potential prognostic value was investigated. Results: Positive miR-361-5p staining was observed in 78.7% (N=295; 78.7% positive, 21.3% negative) in the 375 cases. The clinical outcome of patients with positive miR-361-5p expression [ median disease-free survival (DFS) time 95.52 months] was significantly better than that of patients (median DFS time 82.33 months) with negative miR-361-5p expression (P=0.002). Moreover, the prognostic value of miR-361-5p was most significant among patients with triple-negative breast cancer (TNBC) for DFS (P=0.004). Conclusions: These results indicated that miR-361-5p expression is an independent predictive factor for better prognosis in BC.
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