Journal
JOURNAL OF THORACIC DISEASE
Volume 8, Issue 12, Pages E1589-E1593Publisher
PIONEER BIOSCIENCE PUBL CO
DOI: 10.21037/jtd.2016.12.102
Keywords
Radiation recall dermatitis (RRD); non-small cell lung cancer; pemetrexed; radiation therapy; chemoradiation
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Radiation recall dermatitis (RRD) is an inflammatory reaction in a previously irradiated field subsequent to the administration of pharmacologic or promoting agents. Herein, we describe a 47-year-old man with NSCLC who was treated with radiotherapy and pemetrexed-based chemotherapy three years prior to developing RRD upon resumption of pemetrexed-based chemotherapy. RRD with pemetrexed is rare and consists of five cases reported thus far. Although RRD is a rare phenomenon, it should be considered in any patient with dermatologic reactions that occur at the site of previous exposure to radiation therapy. When severe, RRD can pose a significant, and possibly life-threatening, impediment to the treatment and care of oncology patients. We discuss the time course, natural history, and management of this condition, as well as a connection to internal organ involvement, such as pneumonitis in thoracic oncology patients.
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