4.7 Article

SARS-CoV-2 Cross-Reactivity in Prepandemic Serum from Rural Malaria- Infected Persons, Cambodia

Journal

EMERGING INFECTIOUS DISEASES
Volume 28, Issue 2, Pages 440-444

Publisher

CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2802.211725

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Funding

  1. Intramural Research Program of the NIH, National Institute of Allergy and Infectious Diseases

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Inhabitants of the Greater Mekong Subregion in Cambodia have been exposed to pathogens that may affect serologic cross-reactivity with severe acute respiratory syndrome coronavirus 2. A prepandemic serosurvey of 528 malaria-infected individuals demonstrated higher-than-expected positivity of nonneutralizing IgG to spike and receptor-binding domain antigens. These findings could impact the interpretation of large-scale serosurveys.
Inhabitants of the Greater Mekong Subregion in Cambodia are exposed to pathogens that might influence serologic cross-reactivity with severe acute respiratory syndrome coronavirus 2. A prepandemic serosurvey of 528 malaria-infected persons demonstrated higher-than-expected positivity of nonneutralizing IgG to spike and receptor-binding domain antigens. These findings could affect interpretation of large-scale serosurveys.

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