Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 10, Issue 43, Pages 8852-8855Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2tb01746f
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Funding
- National Natural Science Foundation of China [22074084]
- One hundred people plan of Shanxi Province, Shanxi Province 1331 project'' key innovation team construction plan cultivation team [2018-CT-1]
- 2018 Xiangyuan County Solid Waste Comprehensive Utilization Science and Technology Project [2018XYSDJS-05]
- Shanxi Province Foundation for Returnees [2017-026]
- Shanxi Collaborative Innovation Center of High Value-added Utilization of Coal-related Wastes [201510-B3]
- Shanxi Province Foundation
- Innovative Talents of Higher Education Institutions of Shanxi, Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi [2019L0031]
- Key R&D Program of Shanxi Province [201903D421069]
- Shanxi Province Science Foundation [20210302124012, 201901D111015]
- Shanxi University graduate Innovation Project
- Scientific Instrument Center of Shanxi University [201512]
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A viscosity-sensitive and hepatic-targeted NIR fluorescent probe has been developed for early diagnosis of hepatic fibrosis. The changes in liver viscosity upon hepatotoxicity and treatment offer promising clinical applications.
Herein, a viscosity-sensitive and hepatic-targeted NIR fluorescent probe has been developed for early diagnosis of hepatic fibrosis. Importantly, we observed increased liver viscosity upon CCl4-induced hepatotoxicity and decreased liver viscosity after metformin treatment, which confirmed its high clinical application prospects.
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