Journal
BIOMATERIALS ADVANCES
Volume 141, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bioadv.2022.213129
Keywords
Chitosan; Photothermal therapy; Antibacterial; Antibiofilm; Near-infrared
Categories
Funding
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2021H1D3A2A01098535]
- National Research Foundation of Korea [2022R1I1A1A01067464]
- Korean Ministry of Education, Science Technology [2016R1D1A3B0201175615]
- Institute of Information & Communications Technology Planning & Evaluation (IITP) - Ministry of Science and ICT (MSIT), Korea [IITP-2022-2020-001612]
- National Research Foundation of Korea [2022R1I1A1A01067464] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This work developed a pH/NIR responsive antibacterial agent that shows high antibacterial efficiency and low cytotoxicity. The agent utilizes electrostatic interactions to bind with bacteria and utilizes photothermal effects to kill bacterial pathogens.
This work developed a pH/NIR responsive antibacterial agent (CS-FeNPs) composed of chitosan (CS) and Fe3O4 nanoparticles (FeNPs). CS triggers bacterial attraction through surface charge, while Fe acts as a photothermal agent (PTA). The CS-Fe NPs exhibited antibacterial and antibiofilm activity against both bacteria (G+/G-). However, higher activity was observed against bacteria (G-) due to electrostatic interactions. The CS-FeNPs bind with the bacterial membrane through electrostatic interactions and disturb bacterial cells. Later, in an acidic environment, CS-FeNPs bind with bacterial membrane, and NIR irradiation leads the antibacterial activity. CS-FeNPs exhibited a potential photothermal conversion efficiency (eta) of 21.53 %. Thus, it converts NIR irradiation into heat to kill the bacterial pathogen. The CS-FeNPs were found to be less cytotoxic with great antibacterial efficiency on planktonic bacteria and their biofilm, which indicates that they deserve to develop potential and safe treatment strategies for the treatment of bacterial infections.
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