Expression of Estrogen Receptor Beta 2 in Laryngeal Cancer and Its Relationship with Lymph Node Metastasis

Objective: This study aimed to investigate the expression of estrogen receptor beta 2 receptor in laryngeal squamous cell carcinomas and its relationship with lymph node metastasis. Methods: Histopathological specimens of laryngeal squamous cell carcinoma patients who underwent laryngectomy and neck dissection were evaluated retrospectively. The patients were divided into 2 groups according to the presence of lymph node metastasis. Estrogen receptor beta 2, Ki-67, and p53 antibodies were studied by immunohistochemical methods in the tumoral and non-tumoral tissue specimens. The evaluation of immunohistochemical staining pattern was evaluated with Allred scores. The difference between tumoral and non-tumoral tissues of estrogen receptor beta 2 Allred scores and the relationship of lymph node metastasis with Allred scores of estrogen receptor beta 2 were examined and correlated with Ki-67 and p53 expression. Results: This study included 26 patients in lymph node metastasis (+) group and 46 patients in lymph node metastasis (-) with a total number of 72 patients. There was a significantly higher estrogen receptor beta 2 Allred score of tumoral tissue with respect to non-tumoral tissue (P <.001). Nevertheless, there was no significant relationship between lymph node metastasis (+) group and lymph node metastasis (-) group according to tumoral tissue ER112 Allred score (P= .092). Conclusion: Estrogen receptor beta 2 expression was demonstrated significantly in the tumoral tissue of the laryngeal squamous cell carcinoma patients.

Automated summary

This study found a significant increase in the expression of estrogen receptor beta 2 in tumoral tissue of laryngeal squamous cell carcinoma patients, but it was not significantly related to lymph node metastasis.