Recent developments in enantioselective nickel(ii)-catalyzed conjugate additions

This review highlights the recent developments in enantioselective nickel-catalyzed conjugate additions of various nucleophiles to numerous acceptor-activated olefins published since 2016. By the very fact of the lower costs of nickel catalysts in comparison with other transition metals, these reactions represent powerful and economic methodologies for the stereocontrolled formation of carbon-carbon and carbon-heteroatom bonds. When applied to initiate domino reactions, these processes allowed a direct access to a variety of complex and functionalized chiral molecules.

Automated summary

This review provides an overview of the recent developments in enantioselective nickel-catalyzed conjugate additions of various nucleophiles to acceptor-activated olefins since 2016. These reactions offer powerful and cost-effective methodologies for stereocontrolled formation of carbon-carbon and carbon-heteroatom bonds due to the lower costs of nickel catalysts compared to other transition metals. When utilized in domino reactions, these processes enable direct access to a variety of complex and functionalized chiral molecules.