Related references
Note: Only part of the references are listed.A randomised, double-blind, phase III study comparing SB2, an infliximab biosimilar, to the infliximab reference product Remicade in patients with moderate to severe rheumatoid arthritis despite methotrexate therapy
Jung-Yoon Choe et al.
ANNALS OF THE RHEUMATIC DISEASES (2017)
Monoclonal Antibodies Follow Distinct Aggregation Pathways During Production-Relevant Acidic Incubation and Neutralization
Thomas Skamris et al.
PHARMACEUTICAL RESEARCH (2016)
Immunogenicity of biologic agents in rheumatoid arthritis patients: lessons for clinical practice
Thierry Schaeverbeke et al.
RHEUMATOLOGY (2016)
Auto-reactions, autoimmunity and psoriatic arthritis
Maria Sole Chimenti et al.
AUTOIMMUNITY REVIEWS (2015)
Immunogenicity assessment of biotherapeutic products: An overview of assays and their utility
Meenu Wadhwa et al.
BIOLOGICALS (2015)
Aggregate structure, morphology and the effect of aggregation mechanisms on viscosity at elevated protein concentrations
Gregory V. Barnett et al.
BIOPHYSICAL CHEMISTRY (2015)
Glycoengineering of Chinese hamster ovary cells for enhanced erythropoietin N-glycan branching and sialylation
Bojiao Yin et al.
BIOTECHNOLOGY AND BIOENGINEERING (2015)
Fc glycans of therapeutic antibodies as critical quality attributes
Dietmar Reusch et al.
GLYCOBIOLOGY (2015)
Anaphylaxis to the Carbohydrate Side Chain Alpha-gal
Thomas A. E. Platts-Mills et al.
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (2015)
Transient conformational modification of immunoglobulin G during purification by protein A affinity chromatography
Pete Gagnon et al.
JOURNAL OF CHROMATOGRAPHY A (2015)
Immunogenicity of Biotherapy Used in Psoriasis: The Science Behind the Scenes
Denis Jullien et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)
Do Not Drop: Mechanical Shock in Vials Causes Cavitation, Protein Aggregation, and Particle Formation
Theodore W. Randolph et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2015)
Protein Adsorption, Desorption, and Aggregation Mediated by Solid-Liquid Interfaces
Tatiana Perevozchikova et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2015)
Antibody Glycosylation and Its Impact on the Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies and Fc-Fusion Proteins
Liming Liu
JOURNAL OF PHARMACEUTICAL SCIENCES (2015)
Dextrose-mediated aggregation of therapeutic monoclonal antibodies in human plasma: Implication of isoelectric precipitation of complement proteins
Shen Luo et al.
MABS (2015)
Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation
Ewald T. J. van den Bremer et al.
MABS (2015)
The criticality of high-resolution N-linked carbohydrate assays and detailed characterization of antibody effector function in the context of biosimilar development
Lowell J. Brady et al.
MABS (2015)
Effect of protein aggregates on characterization of FcRn binding of Fc-fusion therapeutics
Adriana Bajardi-Taccioli et al.
MOLECULAR IMMUNOLOGY (2015)
Tyrosine Sulfation as a Protein Post-Translational Modification
Yuh-Shyong Yang et al.
MOLECULES (2015)
Inhibitor development in non-severe haemophilia across Europe
Kathelijn Fischer et al.
THROMBOSIS AND HAEMOSTASIS (2015)
Anti-carbamylated protein antibodies in the pre-symptomatic phase of rheumatoid arthritis, their relationship with multiple anti-citrulline peptide antibodies and association with radiological damage
Mikael Brink et al.
ARTHRITIS RESEARCH & THERAPY (2015)
Anti-TNF levels and anti-drug antibodies, immunosuppressants and clinical outcomes in inflammatory bowel disease
Christina Ha et al.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2015)
The Role of Posttranslational Protein Modifications in Rheumatological Diseases: Focus on Rheumatoid Arthritis
Andrea Mastrangelo et al.
JOURNAL OF IMMUNOLOGY RESEARCH (2015)
Citrullination and carbamylation in the pathophysiology of rheumatoid arthritis
Ger J. M. Pruijn
FRONTIERS IN IMMUNOLOGY (2015)
Post-translational structural modifications of immunoglobulin G and their effect on biological activity
Laura K. Hmiel et al.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2015)
The application of targeted mass spectrometry-based strategies to the detection and localization of post-translational modifications
Navin Chicooree et al.
MASS SPECTROMETRY REVIEWS (2015)
Incidence of erythropoietin antibody-mediated pure red cell aplasia: the Prospective Immunogenicity Surveillance Registry (PRIMS)
Iain C. Macdougall et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2015)
Investigation of the Immunogenicity of Different Types of Aggregates of a Murine Monoclonal Antibody in Mice
Angelika J. Freitag et al.
PHARMACEUTICAL RESEARCH (2015)
In Vitro Glycoengineering of IgG1 and Its Effect on Fc Receptor Binding and ADCC Activity
Marco Thomann et al.
PLOS ONE (2015)
IgG Conformer's Binding to Amyloidogenic Aggregates
Monichan Phay et al.
PLOS ONE (2015)
The Role of Citrullinated Protein Antibodies in Predicting Erosive Disease in Rheumatoid Arthritis: A Systematic Literature Review and Meta-Analysis
A. A. Jilani et al.
INTERNATIONAL JOURNAL OF RHEUMATOLOGY (2015)
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update
Josef S. Smolen et al.
ANNALS OF THE RHEUMATIC DISEASES (2014)
Antibodies and protein misfolding: From structural research tools to therapeutic strategies
Erwin De Genst et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2014)
Control of galactosylated glycoforms distribution in cell culture system
Neil A. McCracken et al.
BIOTECHNOLOGY PROGRESS (2014)
Reduction in C-terminal amidated species of recombinant monoclonal antibodies by genetic modification of CHO cells
Mihaela Skulj et al.
BMC BIOTECHNOLOGY (2014)
The structural role of receptor tyrosine sulfation in chemokine recognition
Justin P. Ludeman et al.
BRITISH JOURNAL OF PHARMACOLOGY (2014)
Protein aggregation and its impact on product quality
Christopher J. Roberts
CURRENT OPINION IN BIOTECHNOLOGY (2014)
Exploiting the proteomics revolution in biotechnology: from disease and antibody targets to optimizing bioprocess development
Kelley M. Heffner et al.
CURRENT OPINION IN BIOTECHNOLOGY (2014)
Diversity in structure and functions of antibody sialylation in the Fc
T. Shantha Raju et al.
CURRENT OPINION IN BIOTECHNOLOGY (2014)
Chemical biology of antigen presentation by MHC molecules
Sander I. van Kasteren et al.
CURRENT OPINION IN IMMUNOLOGY (2014)
Stability engineering of the human antibody repertoire
Romain Rouet et al.
FEBS LETTERS (2014)
ANTI-TNF AGENTS AS THERAPEUTIC CHOICE IN IMMUNE-MEDIATED INFLAMMATORY DISEASES: FOCUS ON ADALIMUMAB
A. Armuzzi et al.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2014)
Dynamics of Inter-heavy Chain Interactions in Human Immunoglobulin G (IgG) Subclasses Studied by Kinetic Fab Arm Exchange
Theo Rispens et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Structural Characterization of IgG1 mAb Aggregates and Particles Generated Under Various Stress Conditions
Srivalli N. Telikepalli et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2014)
In vitro and in vivo modifications of recombinant and human IgG antibodies
Hongcheng Liu et al.
MABS (2014)
Autoantibodies to Posttranslational Modifications in Rheumatoid Arthritis
Agata N. Burska et al.
MEDIATORS OF INFLAMMATION (2014)
Performing native mass spectrometry analysis on therapeutic antibodies
Natalie J. Thompson et al.
METHODS (2014)
How Bio-questionable are the Different Recombinant Human Erythropoietin Copy Products in Thailand?
Liem Andhyk Halim et al.
PHARMACEUTICAL RESEARCH (2014)
Improved Expression of Recombinant Human Factor IX by Co-expression of GGCX, VKOR and Furin
Jianming Liu et al.
PROTEIN JOURNAL (2014)
Immunoglobulin light chain amyloidosis
Giampaolo Merlini et al.
EXPERT REVIEW OF HEMATOLOGY (2014)
Lasting power of new clotting proteins
Jerry S. Powell
HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2014)
Peptidylarginine Deiminase 4 Contributes to Tumor Necrosis Factor α-Induced Inflammatory Arthritis
Miriam A. Shelef et al.
ARTHRITIS & RHEUMATOLOGY (2014)
IgG subclasses and allotypes: from structure to effector functions
Gestur Vidarsson et al.
FRONTIERS IN IMMUNOLOGY (2014)
The impact of the endoplasmic reticulum protein-folding environment on cancer development
Miao Wang et al.
NATURE REVIEWS CANCER (2014)
Antidrug antibodies (ADAb) to tumour necrosis factor (TNF)-specific neutralising agents in chronic inflammatory diseases: a real issue, a clinical perspective
Fabien B. Vincent et al.
ANNALS OF THE RHEUMATIC DISEASES (2013)
The impact of mass spectrometry on the study of intact antibodies: from post-translational modifications to structural analysis
Natalie J. Thompson et al.
CHEMICAL COMMUNICATIONS (2013)
Pyroglutamate-Modified Amyloid Beta Peptides: Emerging Targets for Alzheimer's Disease Immunotherapy
Roxanna Perez-Garmendia et al.
CURRENT NEUROPHARMACOLOGY (2013)
Expression of recombinant glycoproteins in mammalian cells: towards an integrative approach to structural biology
A. Radu Aricescu et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2013)
C-terminal modification of monoclonal antibody drugs: Amidated species as a general product-related substance
Masahiro Tsubaki et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2013)
The identification of free cysteine residues within antibodies and a potential role for free cysteine residues in covalent aggregation because of agitation stress
Joon H. Huh et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2013)
Crystal structure of the human IgG4 CH3 dimer reveals the role of Arg409 in the mechanism of Fab-arm exchange
Anna M. Davies et al.
MOLECULAR IMMUNOLOGY (2013)
Fc-Fc interactions of human IgG4 require dissociation of heavy chains and are formed predominantly by the intra-chain hinge isomer
Theo Rispens et al.
MOLECULAR IMMUNOLOGY (2013)
Aggregation of biopharmaceuticals in human plasma and human serum Implications for drug research and development
Tudor Arvinte et al.
MABS (2013)
Conformational characterization of the charge variants of a human IgG1 monoclonal antibody using H/D exchange mass spectrometry
Liangjie Tang et al.
MABS (2013)
Top-down mass spectrometry for the analysis of combinatorial post-translational modifications
Francesco Lanucara et al.
MASS SPECTROMETRY REVIEWS (2013)
Characterization of Therapeutic Monoclonal Antibodies Reveals Differences Between In Vitro and In Vivo Time-Course Studies
Sheng Yin et al.
PHARMACEUTICAL RESEARCH (2013)
Discovery of the natural anti-Gal antibody and its past and future relevance to medicine
Uri Galili
XENOTRANSPLANTATION (2013)
Isotype and glycoform selection for antibody therapeutics
Roy Jefferis
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2012)
Biosimilar recombinant human erythropoietins (epoetins) and future erythropoiesis-stimulating treatments
Wolfgang Jelkmann
EXPERT OPINION ON BIOLOGICAL THERAPY (2012)
The human phosphatase interactome: An intricate family portrait
Francesca Sacco et al.
FEBS LETTERS (2012)
Rates and impact of human antibody glycation in vivo
Andrew M. Goetze et al.
GLYCOBIOLOGY (2012)
Thioredoxin 1 is responsible for antibody disulfide reduction in CHO cell culture
Kristen L. Koterba et al.
JOURNAL OF BIOTECHNOLOGY (2012)
Antibody-mediated pure red cell aplasia in chronic kidney disease patients receiving erythropoiesis-stimulating agents: new insights
Iain C. Macdougall et al.
KIDNEY INTERNATIONAL (2012)
Disulfide bond structures of IgG molecules Structural variations, chemical modifications and possible impacts to stability and biological function
Hongcheng Liu et al.
MABS (2012)
Simultaneous Assessment of Asp Isomerization and Asn Deamidation in Recombinant Antibodies by LC-MS following Incubation at Elevated Temperatures
Katharina Diepold et al.
PLOS ONE (2012)
Detection and Characterization of Subvisible Aggregates of Monoclonal IgG in Serum
Vasco Filipe et al.
PHARMACEUTICAL RESEARCH (2012)
A method for N-terminal de novo sequencing of N-alpha-blocked proteins by mass spectrometry
Chihiro Nakajima et al.
ANALYST (2011)
Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies
Waleed Alduaij et al.
BLOOD (2011)
Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies
Gerhard Niederfellner et al.
BLOOD (2011)
N-terminal Glutamate to Pyroglutamate Conversion in Vivo for Human IgG2 Antibodies
Y. Diana Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Erythropoiesis-stimulating agents and pure red-cell aplasia: you can't fool Mother Nature
Jay B. Wish
KIDNEY INTERNATIONAL (2011)
Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies
Weirong Wang et al.
MOLECULAR IMMUNOLOGY (2011)
Aggregation, immune complexes and immunogenicity
Roy Jefferis
MABS (2011)
2nd Charles Richet et Jules Hericourt Workshop Therapeutic antibodies and anaphylaxis; May 31-June 1, 2011; Tours, France
Arnaud Daguet et al.
MABS (2011)
Golgi Glycosylation
Pamela Stanley
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)
Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database
George A. Khoury et al.
SCIENTIFIC REPORTS (2011)
Mechanisms of Unintended Amino Acid Sequence Changes in Recombinant Monoclonal Antibodies Expressed in Chinese Hamster Ovary (CHO) Cells
Donglin Guo et al.
BIOTECHNOLOGY AND BIOENGINEERING (2010)
Mass spectrometric analysis, automated identification and complete annotation of O-linked glycopeptides
Zsuzsa Darula et al.
EUROPEAN JOURNAL OF MASS SPECTROMETRY (2010)
A Novel Strategy To Reduce the Immunogenicity of Biological Therapies
Jennifer Somerfield et al.
JOURNAL OF IMMUNOLOGY (2010)
Rapid comparison of a candidate biosimilar to an innovator monoclonal antibody with advanced liquid chromatography and mass spectrometry technologies
Hongwei Xie et al.
MABS (2010)
Stability of IgG isotypes in serum
Ivan R. Correia
MABS (2010)
Charge variants in IgG1 Isolation, characterization, in vitro binding properties and pharmacokinetics in rats
Leslie A. Khawli et al.
MABS (2010)
Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins
Carlos J. Bosques et al.
NATURE BIOTECHNOLOGY (2010)
Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns
Martin F. Bachmann et al.
NATURE REVIEWS IMMUNOLOGY (2010)
Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody
Josef Vlasak et al.
ANALYTICAL BIOCHEMISTRY (2009)
Extending Mass Spectrometry Contribution to Therapeutic Monoclonal Antibody Lead Optimization: Characterization of Immune Complexes Using Noncovalent ESI-MS
Cedric Atmanene et al.
ANALYTICAL CHEMISTRY (2009)
Value of Anti-Modified Citrullinated Vimentin and Third-Generation Anti-Cyclic Citrullinated Peptide Compared With Second-Generation Anti-Cyclic Citrullinated Peptide and Rheumatoid Factor in Predicting Disease Outcome in Undifferentiated Arthritis and Rheumatoid Arthritis
Michael P. M. van der Linden et al.
ARTHRITIS AND RHEUMATISM (2009)
Human antibody Fc deamidation in vivo
Y. Diana Liu et al.
BIOLOGICALS (2009)
N-Linked Glycosylation is an Important Parameter for Optimal Selection of Cell Lines Producing Biopharmaceutical Human IgG
Patrick H. C. van Berkel et al.
BIOTECHNOLOGY PROGRESS (2009)
Specificity and affinity of human Fcγ receptors and their polymorphic variants for human IgG subclasses
Pierre Bruhns et al.
BLOOD (2009)
Impact of Illegal Trade on the Quality of Epoetin Alfa in Thailand
Fotis Fotiou et al.
CLINICAL THERAPEUTICS (2009)
Aggregation-Prone Motifs in Human Immunoglobulin G
Naresh Chennamsetty et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
Effects of antibody affinity and antigen valence on molecular forms of immune complexes
Masayuki Oda et al.
MOLECULAR IMMUNOLOGY (2009)
Impact of methionine oxidation on the binding of human IgG1 to FcRn and Fcγ receptors
Andrea Bertolotti-Ciarlet et al.
MOLECULAR IMMUNOLOGY (2009)
Potential aggregation prone regions in biotherapeutics A survey of commercial monoclonal antibodies
Xiaoling Wang et al.
MABS (2009)
Human immunoglobulin allotypes Possible implications for immunogenicity
Roy Jefferis et al.
MABS (2009)
Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn
Hai Pan et al.
PROTEIN SCIENCE (2009)
Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody
Sandipan Sinha et al.
PROTEIN SCIENCE (2009)
Human IgG2 antibodies display disulfide-mediated structural isoforms
Jette Wypych et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Structural and functional characterization of disulfide isoforms of the human IgG2 subclass
Thomas M. Dillon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Effect of methionine oxidation of a recombinant monoclonal antibody on the binding affinity to protein A and protein G
Georgeen Gaza-Bulseco et al.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2008)
Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis
Xiaoyan Zhao et al.
ARTHRITIS RESEARCH & THERAPY (2008)
Mammalian glycosylation in immunity
Jamey D. Marth et al.
NATURE REVIEWS IMMUNOLOGY (2008)
Comparative analyses of complex formation and binding sites between human tumor necrosis factor-alpha and its three antagonists elucidate their different neutralizing mechanisms
Min-Soo Kim et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Evaluation of protein N-glycosylation in 2-DE:: Erythropoietin as a study case
Esther Llop et al.
PROTEOMICS (2007)
Contrasting glycosylation profiles between Fab and Fc of a human IgG protein studied by electrospray ionization mass spectrometry
Yusuke Mimura et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2007)
Enhanced binding affinity for FcγRIIIa of fucose-negative antibody is sufficient to induce maximal antibody-dependent cellular cytotoxicity
Kazuhiro Masuda et al.
MOLECULAR IMMUNOLOGY (2007)
Comparison of methionine oxidation in thermal stability and chemically stressed samples of a fully human monoclonal antibody
Chris Churnsae et al.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2007)
A comparative study of different vector designs for the mammalian expression of recombinant IgG antibodies
Jiandong Li et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2007)
Antibody structure, instability, and formulation
Wei Wang et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2007)
Post-translational modifications in the context of therapeutic proteins
Gary Walsh et al.
NATURE BIOTECHNOLOGY (2006)
Current and future issues in the manufacturing and development of monoclonal antibodies
Steven Kozlowski et al.
ADVANCED DRUG DELIVERY REVIEWS (2006)
Effects of protein aggregates: An immunologic perspective
Amy S. Rosenberg
AAPS JOURNAL (2006)
Post-translational modifications in proteins involved in blood coagulation
K Hansson et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2005)
Identification and characterization of deamidation sites in the conserved regions of human Immunoglobulin Gamma antibodies
D Chelius et al.
ANALYTICAL CHEMISTRY (2005)
In vivo deamidation characterization of monoclonal antibody by LC/MS/MS
LH Huang et al.
ANALYTICAL CHEMISTRY (2005)
Annotation of post-translational modifications in the Swiss-Prot knowledge base
N Farriol-Mathis et al.
PROTEOMICS (2004)
Understanding the cell biology of antigen presentation: the dendritic cell contribution
E Gatti et al.
CURRENT OPINION IN CELL BIOLOGY (2003)
Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120
H Choe et al.
CELL (2003)
Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity
S Krapp et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Biophysical properties of human antibody variable domains
S Ewert et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
The protein kinase complement of the human genome
G Manning et al.
SCIENCE (2002)
Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors
S Costagliola et al.
EMBO JOURNAL (2002)
Role of oligosaccharide residues of IgG1-Fc in FcγRIIb binding
Y Mimura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Probing molecular interactions in intact antibody: Antigen complexes, an electrospray time-of-flight mass spectrometry approach
MA Tito et al.
BIOPHYSICAL JOURNAL (2001)
Identification of multiple sources of charge heterogeneity in a recombinant antibody
RJ Harris et al.
JOURNAL OF CHROMATOGRAPHY B (2001)
The influence of glycosylation on the thermal stability and effector function expression of human IgG1-Fc: properties of a series of truncated glycoforms
Y Mimura et al.
MOLECULAR IMMUNOLOGY (2000)