Journal
NEW JOURNAL OF CHEMISTRY
Volume 46, Issue 44, Pages 21176-21180Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2nj04127h
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Funding
- National Natural Science Foundation of China [22078192]
- Fund for Scientific Research-Flanders-FWO (Belgium)
- RUDN University Strategic Academic Leadership Program
- China Scholarship Council (CSC)
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A novel strategy for the synthesis of various N-alkenylisoquinolinones is reported, featuring broad functional group tolerance and good chemoselectivity. This strategy involves sequential palladium-catalyzed cyclization and C-4-O bond cleavage of oxazolidines to form carbon-carbon and carbon-oxygen double bonds. Additionally, the practical value of this method is explored by conducting a millimole reaction and utilizing palladium-catalyzed C-H arylation and visible-light-assisted photocatalyzed conversion of the cyclic enamide to valuable compounds.
A novel strategy for the synthesis of various N-alkenylisoquinolinones is reported, which features broad functional group tolerance, and good chemoselectivity. This reaction proceeds through sequential palladium-catalyzed cyclization and C-4-O bond cleavage of oxazolidines to form carbon-carbon and carbon-oxygen double bonds. In addition, the practical value of this method has been explored by conducting a millimole reaction, as well as via the palladium-catalyzed C-H arylation and visible-light-assisted photocatalyzed conversion of the cyclic enamide to valuable compounds.
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