Journal
JACS AU
Volume 2, Issue 11, Pages 2381-2399Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacsau.2c00292
Keywords
Artificial molecular machines; DNA nanotechnology; DNA framework; Functional nucleic acids; Nanomedicine
Categories
Funding
- National Science Foundation
- National Key R&D Program of China [2021YFF1200300]
- NSFC [T2188102, 22025404, 22174092, 21904041]
- Natural Science Foundation of Shanghai [19JC1410300, 21ZR1439600]
- Innovative Research Team of High-Level Local Universities in Shanghai [SHSMUZLCX20212602]
- K. C. Wong Foundation at Shanghai Jiao Tong University
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Artificial molecular machines have been widely used in various fields, and recent advancements in DNA have led to the development of DNA-based artificial molecular machines. The programmability of DNA allows for the design of complex machines that can exert mechanical force or motion in a controllable and modular manner. This Perspective highlights the potential and strategies for constructing DNA-based molecular machines, and discusses the challenges and opportunities in biophysics, biosensing, and biocomputing.
Artificial molecular machines have found widespread applications ranging from fundamental studies to biomedicine. More recent advances in exploiting unique physical and chemical properties of DNA have led to the development of DNA-based artificial molecular machines. The unprecedented programmability of DNA provides a powerful means to design complex and sophisticated DNA-based molecular machines that can exert mechanical force or motion to realize complex tasks in a controllable, modular fashion. This Perspective highlights the potential and strategies to construct artificial molecular machines using double-stranded DNA, functional nucleic acids, and DNA frameworks, which enable improved control over reaction pathways and motion behaviors. We also outline the challenges and opportunities of using DNA-based molecular machines for biophysics, biosensing, and biocomputing.
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