Journal
ENDOCRINOLOGY
Volume 163, Issue 12, Pages -Publisher
ENDOCRINE SOC
DOI: 10.1210/endocr/bqac164
Keywords
androgen excess; gene-modified; metabolic; reproductive; behavior; developmental programming; transgenerational
Categories
Funding
- Swedish Medical Research Council [2018-02435]
- Novo Nordisk Foundation [NNF22OC0072904]
- Diabetes Diabetesfonden [DIA2021-633]
- Strategic Research Program in Diabetes at the Karolinska Institutet
- Karolinska Institutet KID funding [2020-00990]
- Vinnova [2018-02435] Funding Source: Vinnova
- Swedish Research Council [2018-02435] Funding Source: Swedish Research Council
- Formas [2018-02435] Funding Source: Formas
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Polycystic ovary syndrome (PCOS) is a complex disease affecting women of reproductive age, with unclear etiology. Animal models provide an important approach to study the pathophysiology, genetics, prevention, and treatment of PCOS.
Polycystic ovary syndrome (PCOS) is a complex disease affecting up to 15% of women of reproductive age. Women with PCOS suffer from reproductive dysfunctions with excessive androgen secretion and irregular ovulation, leading to reduced fertility and pregnancy complications. The syndrome is associated with a wide range of comorbidities including type 2 diabetes, obesity, and psychiatric disorders. Despite the high prevalence of PCOS, its etiology remains unclear. To understand the pathophysiology of PCOS, how it is inherited, and how to predict PCOS, and prevent and treat women with the syndrome, animal models provide an important approach to answering these fundamental questions. This minireview summarizes recent investigative efforts on PCOS-like rodent models aiming to define underlying mechanisms of the disease and provide guidance in model selection. The focus is on new genetic rodent models, on a naturally occurring rodent model, and provides an update on prenatal and peripubertal exposure models.
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