Journal
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
Volume 7, Issue -, Pages 43-45Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jgar.2016.07.007
Keywords
Agar dilution; Broth microdilution; Clostridium difficile; Japan; Metronidazole; Vancomycin
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Funding
- Charitable Trust Laboratory Medicine Research Foundation of Japan
- Kurozumi Medical Foundation
- Grants-in-Aid for Scientific Research [15K08837] Funding Source: KAKEN
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In this study, the performance of the broth microdilution (BMD) method for testing the antimicrobial susceptibility of Clostridium difficile in comparison with the agar dilution (AD) method used by the Clinical and Laboratory Standards Institute (CLSI) was evaluated. In total, 70 non-duplicate C difficile clinical isolates were used in this study. The minimum inhibitory concentrations (MICs) of clindamycin, moxifloxacin, metronidazole and vancomycin were examined using AD and BMD. The results showed that BMD is acceptable for routine antimicrobial susceptibility testing of C difficile as its performance was comparable with that of the AD method. In addition, it was noted that metronidazole- and vancomycin-resistant isolates are extremely rare in Japan. (C) 2016 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.
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