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Article Urology & Nephrology

Maturation of GFR in Term-Born Neonates: An Individual Participant Data Meta-Analysis

Nori J. L. Smeets et al.

Summary: This study establishes reference values for GFR in healthy, term-born neonates through an analysis of individual participant data (IPD). The study also optimizes the estimation of GFR using creatinine levels. The findings reveal a biphasic increase in GFR in neonates, with the largest increase occurring between days 1 and 5 after birth.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

Article Pediatrics

Reliability of glomerular filtration rate estimating formulas compared to iohexol plasma clearance in critically ill children

Evelyn Dhont et al.

Summary: The reliability of common estimated glomerular filtration rate (eGFR) formulas was assessed in a pediatric intensive care unit (PICU) population. The study found that most eGFR formulas overestimated the measured GFR (mGFR) in critically ill children, with poor precision. Therefore, clinicians should use these formulas with caution when guiding intensive care decision-making and drug dosing.

EUROPEAN JOURNAL OF PEDIATRICS (2022)