inPhocus: Current State and Challenges of Phage Research in Singapore

Bacteriophages and phage-derived proteins are a promising class of antibacterial agents that experience a growing worldwide interest. To map ongoing phage research in Singapore and neighboring countries, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore (NTU) and Yong Loo Lin School of Medicine, National University of Singapore (NUS) recently co-organized a virtual symposium on Bacteriophage and Bacteriophage-Derived Technologies, which was attended by more than 80 participants. Topics were discussed relating to phage life cycles, diversity, the roles of phages in biofilms and the human gut microbiome, engineered phage lysins to combat polymicrobial infections in wounds, and the challenges and prospects of clinical phage therapy. This perspective summarizes major points discussed during the symposium and new perceptions that emerged after the panel discussion.

Automated summary

This article summarizes the ongoing research on bacteriophages and phage-derived technologies in Singapore and neighboring countries. The symposium discussed topics such as the life cycles and diversity of phages, their roles in biofilms and the human gut microbiome, engineered phage lysins for treating polymicrobial infections in wounds, and the challenges and prospects of clinical phage therapy.