Dynamics of the alkyne ? copper(i) interaction and its use in a heteroleptic four-component catalytic rotor

The HETPYNE (HETeroleptic Phenanthroline and alkYNE metal) and DABCO & BULL;(zinc porphyrin)(2) interactions were used to assemble the four-component nanorotor ROT-1 that exhibited a highly dynamic alkyne & RARR; copper(i) dissociation (k(298) = 240 kHz) at 298 K. Quantitative click reaction transformed ROT-1 into the new rotor ROT-2 (k(298) = 77 kHz) with a triazole & RARR; copper(i) linkage thus opening perspectives for bioorthogonal click strategies to biohybrid machinery.

Automated summary

The HETPYNE and DABCO & BULL interactions were used to assemble the nanorotor ROT-1, which exhibited a highly dynamic alkyne & RARR; copper(i) dissociation. Quantitative click reaction transformed ROT-1 into the new rotor ROT-2 with a triazole & RARR; copper(i) linkage, opening perspectives for bioorthogonal click strategies to biohybrid machinery.