4.7 Article

An NO-responsive probe for detecting acute inflammation using NIR-II fluorescence/optoacoustic imaging

Journal

CHEMICAL COMMUNICATIONS
Volume 58, Issue 94, Pages 13123-13126

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc05386a

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Funding

  1. NSFC [21875069, 21788102]
  2. Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates [2019B030301003]

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An NO-responsive probe has been developed for imaging acute inflammation, which exhibits turn-on NIR-II fluorescence and optoacoustic signals in situ NO at acute inflammation sites such as LPS-induced acute dermatitis and MIA-induced acute joint inflammation.
An NO-responsive probe for imaging acute inflammation was developed. The probe responds to in situ NO in acute inflammation sites such as LPS-induced acute dermatitis and MIA-induced acute joint inflammation with turn-on NIR-II fluorescence and optoacoustic signals.

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