Moving Prostate Cancer Polygenic Risk Scores from Research Towards Clinical Practice

Review Oncology

Inherited risk assessment and its clinical utility for predicting prostate cancer from diagnostic prostate biopsies

Jianfeng Xu et al.

Summary: This review summarizes the findings of studies on germline variants in prostate cancer (PCa) and their clinical validity. It highlights the associations between SNPs, GRS, and RPMs in certain genes and PCa risk. The review also emphasizes the need for prospective studies to evaluate the predictive ability of these inherited risk measures in PCa detection rates.

PROSTATE CANCER AND PROSTATIC DISEASES (2022)

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Article Genetics & Heredity

Genetic factors associated with prostate cancer conversion from active surveillance to treatment

Yu Jiang et al.

Summary: Men diagnosed with low-risk prostate cancer who initially choose active surveillance may eventually convert to active treatment due to genetic factors that predispose to aggressive tumors. This study identified genetic variants associated with conversion from active surveillance to active treatment, suggesting that germline genetics may help individualize management decisions for low-risk prostate cancer.

HUMAN GENETICS AND GENOMICS ADVANCES (2022)

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Article Genetics & Heredity

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

David Conti et al.

Summary: The study identified 86 new genetic risk variants associated with prostate cancer, bringing the total known risk variants to 269. The top genetic risk score decile showed different odds ratios for men of European, African, and East Asian ancestries, highlighting the role of germline variation and providing a potential approach for personalized risk prediction.

NATURE GENETICS (2021)

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Article Urology & Nephrology

Performance of Three Inherited Risk Measures for Predicting Prostate Cancer Incidence and Mortality: A Population-based Prospective Analysis

Zhuqing Shi et al.

Summary: The study suggests that genetic risk score (GRS) complements family history and rare pathogenic mutations as genetic risk measures for assessing the incidence and mortality of prostate cancer.

EUROPEAN UROLOGY (2021)

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Article Multidisciplinary Sciences

Polygenic hazard score is associated with prostate cancer in multi-ethnic populations

Minh-Phuong Huynh-Le et al.

Summary: The study found that a polygenic hazard score can risk-stratify men for prostate cancer in a multi-ethnic dataset, with significant and effective associations observed across different genetic ancestries.

NATURE COMMUNICATIONS (2021)

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Review Medicine, General & Internal