Moving Prostate Cancer Polygenic Risk Scores from Research Towards Clinical Practice

Recent advances in our understanding of genetic factors that contribute to prostate can-cer (PCa) susceptibility have the potential to improve disease screening, diagnosis, and treatment. Genetic risk scores in particular can more accurately inform patients of their risk of being diagnosed with PCa, which may help in decisions on whether to undergo prostate-specific antigen screening or prostate biopsy. Genetic information may also be useful in helping patients understand the etiology of their PCa and whether their fam-ily members should undergo more intensive screening.Patient summary: This mini review discusses recent advances in our understanding of how genetic factors influence a man's risk of developing prostate cancer. This informa-tion has the potential to improve screening, diagnosis, and patient counseling following a diagnosis of prostate cancer.(c) 2022 European Association of Urology. Published by Elsevier B.V. All rights reserved.

Automated summary

This mini review discusses recent advances in our understanding of how genetic factors influence a man's risk of developing prostate cancer. This information has the potential to improve screening, diagnosis, and patient counseling following a diagnosis of prostate cancer.