Journal
CHEMICAL SCIENCE
Volume 13, Issue 45, Pages 13617-13622Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2sc04431e
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Funding
- Anhui Provincial Natural Science Foundation [21772001]
- National Natural Science Foundation of China [GXXT-2020-074]
- University Synergy Innovation Program of Anhui Province [14308121-21P]
- Research Grants Council of Hong Kong [4442827]
- CUHK Direct Fund [2021Szvup147]
- Central Funds Guiding the Local Science and Technology Development of Shenzhen Virtual University Park [XJ2020-072]
- Hong Kong Scholars Program
- Innovation and Technology Commission (HKSAR, China)
- [1808085MB41]
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An operationally simple and environmentally friendly method for the modular and regioselective synthesis of (E)-4-(vinyl or aryl or alkynyl)iminochromenes from propargylamines and S-methylated beta-ketothioamides using FeCl3 in undried acetonitrile and air atmosphere is reported. This method exhibits a broad substrate scope and nice functional group compatibility, providing an efficient access to 3,4-disubstituted iminochromenes.
ortho-Alkynyl quinone methides are well-known four-atom synthons for direct [4 + n] cycloaddition in constructing useful oxa-heterocyclic compounds owing to their high reactivity as well as the thermodynamically favored aromatization nature of this process. Herein we report an operationally simple and eco-friendly protocol for the modular and regioselective access of (E)-4-(vinyl or aryl or alkynyl)iminochromenes from propargylamines and S-methylated beta-ketothioamides in the presence of FeCl3, and particularly under undried acetonitrile and air atmosphere conditions. This method exhibits a broad substrate scope and displays nice functional group compatibility, thus providing an efficient access of 3,4-disubstituted iminochromenes.
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