Journal
DALTON TRANSACTIONS
Volume 51, Issue 47, Pages 18054-18058Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2dt03088h
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Funding
- National Natural Science Foundation of China
- [22075056]
- [21861005]
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A novel copper complex Fc-OD-Cu was synthesized and designed for efficient chemodynamic therapy. Fc-OD-Cu can generate highly reactive hydroxyl radicals through a reaction induced by copper moieties, resulting in higher therapeutic efficiency compared to other compounds.
A triphenylphosphine coordinated Cu(i) complex of Fc-OD-Cu was rationally designed for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a highly toxic hydroxyl radical (OH) via a Fenton-like reaction induced by Cu(i) moieties and simultaneously mediated by ferrocene moieties. As a result, the CDT efficiency of Fc-OD-Cu is higher than that of Ba-OD-Cu (without ferrocene moieties) and Fc-OD (without Cu(i) moieties).
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