A triphenylphosphine coordinated Cu(I) Fenton-like agent with ferrocene moieties for enhanced chemodynamic therapy

A triphenylphosphine coordinated Cu(i) complex of Fc-OD-Cu was rationally designed for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a highly toxic hydroxyl radical (OH) via a Fenton-like reaction induced by Cu(i) moieties and simultaneously mediated by ferrocene moieties. As a result, the CDT efficiency of Fc-OD-Cu is higher than that of Ba-OD-Cu (without ferrocene moieties) and Fc-OD (without Cu(i) moieties).

Automated summary

A novel copper complex Fc-OD-Cu was synthesized and designed for efficient chemodynamic therapy. Fc-OD-Cu can generate highly reactive hydroxyl radicals through a reaction induced by copper moieties, resulting in higher therapeutic efficiency compared to other compounds.