Journal
IN VIVO
Volume 36, Issue 6, Pages 2669-2677Publisher
INT INST ANTICANCER RESEARCH
DOI: 10.21873/invivo.13002
Keywords
Enhancer of zeste homolog 2 (EZH2); genotype; oral cancer; single nucleotide polymorphism; Taiwan
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Funding
- China Medical University, Taichung, Taiwan
- Asia University, Taichung, Taiwan [CMU111-ASIA-01]
- Taichung Veterans General Hospital, Taichung, Taiwan [TCVGH-1117201B]
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The aim of this study was to evaluate the association of EZH2 genotypes with oral cancer risk among Taiwanese and analyze the interaction of EZH2 genotypes with personal behaviors.
Background/Aim: The over-expression of enhancer of zeste homolog 2 (EZH2) protein is found in oral cancer tissues. However, the genetic role of the enhancer of EZH2 in the etiology of oral cancer is unknown. The aim of this study was to evaluate the association of EZH2 genotypes with oral cancer risk among Taiwanese. Materials and Methods: Three polymorphic variants of EZH2, rs887569 (C to T), rs41277434 (A to C), and rs3757441 (T to C), were analyzed regarding their association with oral cancer risk among 958 oral cancer patients and the same number of healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In addition, the interaction of EZH2 rs887569, rs41277434, and rs3757441 genotypes with personal behaviors such as smoking, alcohol drinking, and betel quid chewing were also examined.
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