Journal
ANALYST
Volume 147, Issue 24, Pages 5739-5746Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2an01509a
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Funding
- National Natural Science Foundation of China
- [21974133]
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In this study, an electrochemical sensor based on AuPd@FexOy nanozyme was successfully prepared for accurate detection of H2O2. The sensor exhibited good stability and anti-interference ability, with high sensitivity for in situ real-time detection and quantitative determination of H2O2.
The hydrogen peroxide (H2O2) levels in living organisms and environment have strong effects on many biological processes inducing cell apoptosis/cell necrosis and wound disinfection. Therefore, it is important to have an accurate and in situ detection of H2O2. Herein, an AuPd@FexOy nanozyme-based electrochemical (EC) sensor (termed as AuPd@FexOy NPs/GCE) with good stability and anti-interference ability has been prepared for the detection of H2O2 by differential pulse voltammetry (DPV) and chronoamperometry dual-measurement modes. The AuPd@FexOy NPs/GCE exhibits good linear relationships in the ranges from 13.0 to 6.0 x 10(3) mu M (DPV measurement) and 50 to 1.0 x 10(3) mu M (chronoamperometry measurement), low detection limits (LODs) of 1.6 mu M (DPV measurement) and 3.0 mu M (chronoamperometry measurement) and high sensitivities of 83.8 nA mu M-1 cm(-2) (DPV measurement) and 120.7 nA mu M-1 cm(-2) (chronoamperometry measurement). The practicability of the as-prepared AuPd@FexOy NPs/GCE has been demonstrated by an in situ real-time detection of H2O2 released from adherent living MCF-7 cells triggered by varying amounts of N-formyl-l-methionyl-l-leucyl-l-phenylalanine (FMLP) from 0.5 to 3.0 mu M and the quantitative determination of H2O2 in commercial disinfectants.
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