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Advances in Aptamers-Based Applications in Breast Cancer: Drug Delivery, Therapeutics, and Diagnostics

Journal

Publisher

MDPI
DOI: 10.3390/ijms232214475

Keywords

aptamer; drug delivery; cancer diagnostics; cancer therapy

Funding

  1. Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran [IR.TBZMED.VCR.REC.1399.420]

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This article introduces the application of aptamers in the treatment of breast tumors, including their use as delivery agents and treatment strategies, as well as the chemical synthesis and modification characteristics of aptamers. The article summarizes different aptamer adoption approaches and discusses future developments.
Aptamers are synthetic single-stranded oligonucleotides (such as RNA and DNA) evolved in vitro using Systematic Evolution of Ligands through Exponential enrichment (SELEX) techniques. Aptamers are evolved to have high affinity and specificity to targets; hence, they have a great potential for use in therapeutics as delivery agents and/or in treatment strategies. Aptamers can be chemically synthesized and modified in a cost-effective manner and are easy to hybridize to a variety of nano-particles and other agents which has paved a way for targeted therapy and diagnostics applications such as in breast tumors. In this review, we systematically explain different aptamer adoption approaches to therapeutic or diagnostic uses when addressing breast tumors. We summarize the current therapeutic techniques to address breast tumors including aptamer-base approaches. We discuss the next aptamer-based therapeutic and diagnostic approaches targeting breast tumors. Finally, we provide a perspective on the future of aptamer-based sensors for breast therapeutics and diagnostics. In this section, the therapeutic applications of aptamers will be discussed for the targeting therapy of breast cancer.

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