Synthesis, Crystal Structure, and DNA Binding/Cleavage Properties of a Macrocyclic Heterobinuclear Zn(II)-Ni(II) Complex with Pyridylmethyl Pendant-Arms

A bis-pyridine pendant-armed macrocyclic heterobinuclear Zn(II)-Ni(II) complex [ZnNi(L)](ClO4)(2)center dot H2O (H2L=3,3'-((ethane-1,2-diylbis((pyridin-2-ylmethyl)azanediyl))bis(methylene)) bis(2-hydroxy-5-methylbenzalde-hyde)) has been obtained and characterized by spectroscopy, elemental analysis and single-crystal X-ray diffraction. The coordination environment of Zn(II) and Ni(II) can be described as approximately distorted triangular prism and square pyramid, respectively. The Zn-Ni distance bridged by two phenoxide groups is 0.303 63(6) nm. The interaction between the complex and calf thymus DNA (CT-DNA) has been further confirmed by UV-Vis spectrophotometry, viscosity, and cyclic voltammetry study. The complex showed a good binding property to CT-DNA with a binding constant of 1.05x10(5) L.mol(-1). The DNA cleavage activity has also been investigated using agarose gel electrophoresis. CCDC: 2045334.

Automated summary

A bis-pyridine pendant-armed macrocyclic heterobinuclear Zn(II)-Ni(II) complex has been synthesized and characterized. The structure and interaction of the complex with CT-DNA has been investigated.