Related references
Note: Only part of the references are listed.Calcimimetic and Calcilytic Drugs: Feats, Flops, and Futures
E. F. Nemeth et al.
CALCIFIED TISSUE INTERNATIONAL (2016)
Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor
Katie Leach et al.
CELL RESEARCH (2016)
A G-protein Subunit-11 Loss-of-Function Mutation, Thr54Met, Causes Familial Hypocalciuric Hypercalcemia Type 2 (FHH2)
Caroline M. Gorvin et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2016)
Identification of a G-Protein Subunit-11 Gain-of-Function Mutation, Val340Met, in a Family With Autosomal Dominant Hypocalcemia Type 2 (ADH2)
Sian E. Piret et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2016)
Localization and function of the renal calcium-sensing receptor
Daniela Riccardi et al.
NATURE REVIEWS NEPHROLOGY (2016)
Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism
Christian Santa Maria et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2016)
Activating Calcium-Sensing Receptor Mutations: Prospects for Future Treatment with Calcilytics
Bernhard Mayr et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2016)
Structural mechanism of ligand activation in human calcium-sensing receptor
Yong Geng et al.
ELIFE (2016)
Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist
Chen Zhang et al.
SCIENCE ADVANCES (2016)
A randomized, double-blind, phase 2 study evaluating the safety and efficacy of AMG 416 for the treatment of secondary hyperparathyroidism in hemodialysis patients
Gregory Bell et al.
CURRENT MEDICAL RESEARCH AND OPINION (2015)
The calcium-sensing receptor in bone-mechanistic and therapeutic insights
David Goltzman et al.
NATURE REVIEWS ENDOCRINOLOGY (2015)
Towards tissue-specific pharmacology: insights from the calcium-sensing receptor as a paradigm for GPCR (patho)physiological bias
Katie Leach et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2015)
Critical Cysteine Residues in Both the Calcium-Sensing Receptor and the Allosteric Activator AMG 416 Underlie the Mechanism of Action
Shawn T. Alexander et al.
MOLECULAR PHARMACOLOGY (2015)
Intracellular Ca2+ oscillations generated via the Ca2+ -sensing receptor are mediated by negative feedback by PKCα at Thr888
Steven H. Young et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2014)
Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain
Andrew S. Dore et al.
NATURE (2014)
Cinacalcet Induces Apoptosis in Parathyroid Cells in Patients with Secondary Hyperparathyroidism: Histological and Cytological Analyses
Ryoko Tatsumi et al.
NEPHRON CLINICAL PRACTICE (2014)
Pharmacoperones and the calcium sensing receptor: Exogenous and endogenous regulators
Gerda E. Breitwieser
PHARMACOLOGICAL RESEARCH (2014)
Sensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion
Kristian Daly et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)
Perioperative indicators of hypocalcemia in total thyroidectomy: the role of vitamin D and parathyroid hormone
Eric M. Salinger et al.
AMERICAN JOURNAL OF SURGERY (2013)
Calcimimetic and calcilytic drugs for treating bone and mineral-related disorders
Edward F. Nemeth et al.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2013)
Calcium-sensing receptor (CaSR): Pharmacological properties and signaling pathways
Arthur D. Conigrave et al.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2013)
The calcium sensing receptor life cycle: Trafficking, cell surface expression, and degradation
Gerda E. Breitwieser
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2013)
Impact of Clinically Relevant Mutations on the Pharmacoregulation and Signaling Bias of the Calcium-Sensing Receptor by Positive and Negative Allosteric Modulators
Katie Leach et al.
ENDOCRINOLOGY (2013)
Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3
M. Andrew Nesbit et al.
NATURE GENETICS (2013)
Mutations Affecting G-Protein Subunit α11 in Hypercalcemia and Hypocalcemia
M. Andrew Nesbit et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Pharmacology of AMG 416 (Velcalcetide), a Novel Peptide Agonist of the Calcium-Sensing Receptor, for the Treatment of Secondary Hyperparathyroidism in Hemodialysis Patients
Sarah Walter et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)
Positive and Negative Allosteric Modulators Promote Biased Signaling at the Calcium-Sensing Receptor
Anna E. Davey et al.
ENDOCRINOLOGY (2012)
Differential Gene Expression by Oxyphil and Chief Cells of Human Parathyroid Glands
Cynthia S. Ritter et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)
PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor
Alexandre Loupy et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Calcium Signaling Regulates Trafficking of Familial Hypocalciuric Hypercalcemia (FHH) Mutants of the Calcium Sensing Receptor
Michael P. Grant et al.
MOLECULAR ENDOCRINOLOGY (2012)
Minireview: The Intimate Link Between Calcium Sensing Receptor Trafficking and Signaling: Implications for Disorders of Calcium Homeostasis
Gerda E. Breitwieser
MOLECULAR ENDOCRINOLOGY (2012)
Cinacalcet HCl prevents development of parathyroid gland hyperplasia and reverses established parathyroid gland hyperplasia in a rodent model of CKD
Gerald Miller et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2012)
Cinacalcet HCl Suppresses Cyclin D1 Oncogene-Derived Parathyroid Cell Proliferation in a Murine Model for Primary Hyperparathyroidism
Yasuo Imanishi et al.
CALCIFIED TISSUE INTERNATIONAL (2011)
A novel mutation of the primary protein kinase C phosphorylation site in the calcium-sensing receptor causes autosomal dominant hypocalcemia
Syndia Lazarus et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2011)
JTT-305, an orally active calcium-sensing receptor antagonist, stimulates transient parathyroid hormone release and bone formation in ovariectomized rats
Shuichi Kimura et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2011)
Allosteric Modulation of the Calcium-sensing Receptor by γ-Glutamyl Peptides INHIBITION OF PTH SECRETION, SUPPRESSION OF INTRACELLULAR cAMP LEVELS, AND A COMMON MECHANISM OF ACTION WITH L-AMINO ACIDS
Geoffrey K. Broadhead et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Cinacalcet HCl Reduces Hypercalcemia in Primary Hyperparathyroidism across a Wide Spectrum of Disease Severity
Munro Peacock et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)
Agonist-Driven Maturation and Plasma Membrane Insertion of Calcium-Sensing Receptors Dynamically Control Signal Amplitude
Michael P. Grant et al.
SCIENCE SIGNALING (2011)
Mapping of Human Autoantibody Binding Sites on the Calcium-Sensing Receptor
E. Helen Kemp et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2010)
The diltiazem analog TA-3090 mimics the actions of high extracellular Ca2+ on parathyroid function in dispersed bovine parathyroid cells
Chu J. Chen et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2010)
Polyarginine, polylysine, and protamine mimic the effects of high extracellular calcium concentrations on dispersed bovine parathyroid cells
Edward M. Brown et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2010)
The Calcium-Sensing Receptor and 25-Hydroxyvitamin D-1α-Hydroxylase Interact to Modulate Skeletal Growth and Bone Turnover
Christian Richard et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2010)
Postoperative Calcium Requirements in 6,000 Patients Undergoing Outpatient Parathyroidectomy: Easily Avoiding Symptomatic Hypocalcemia
Marie Vasher et al.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2010)
Broad-spectrum amino acid-sensing class C G-protein coupled receptors: Molecular mechanisms, physiological significance and options for drug development
Arthur D. Conigrave et al.
PHARMACOLOGY & THERAPEUTICS (2010)
Physiology and pathophysiology of the calcium-sensing receptor in the kidney
Daniela Riccardi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2010)
The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion
Lakshmi Kantham et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)
Anti-Parathyroid and Anti-Calcium Sensing Receptor Antibodies in Autoimmune Hypoparathyroidism
Edward M. Brown
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2009)
Adenomatous Human Parathyroid Cells Exhibit Impaired Sensitivity to L-Amino Acids
H. -C. Mun et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)
Thick ascending limb: the Na+:K+:2Cl(-) co-transporter, NKCC2, and the calcium-sensing receptor, CaSR
Gerardo Gamba et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2009)
N-methyl-D-aspartate receptors are expressed in rat parathyroid gland and regulate PTH secretion
Eva Parisi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2009)
Dietary protein and bone health: Roles of amino acid-sensing receptors in the control of calcium metabolism and bone homeostasis
A. D. Conigrave et al.
ANNUAL REVIEW OF NUTRITION (2008)
Hypercalcaemic and hypocalcaemic conditions due to calcium-sensing receptor mutations
Ogo I. Egbuna et al.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2008)
Cinacalcet: pharmacological and clinical aspects
Piergiorgio Messa et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2008)
The Extracellular Calcium-Sensing Receptor (CaSR) Is a Critical Modulator of Skeletal Development
Wenhan Chang et al.
SCIENCE SIGNALING (2008)
Type B γ-aminobutyric acid receptors modulate the function of the extracellular Ca2+-Sensing receptor and cell differentiation in murine growth plate Chondrocytes
Zhiqiang Cheng et al.
ENDOCRINOLOGY (2007)
Complex formation with the type B γ-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor -: Studies with hek-293 cells and neurons
Wenhan Chang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Protein kinase C-mediated phosphorylation of the calcium-sensing receptor is stimulated by receptor activation and attenuated by calyculin-sensitive phosphatase activity
Sarah L. Davies et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Takanori Muto et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Pharmacological characterization of mouse GPRC6A, an L-α-amino-acid receptor modulated by divalent cations
B. Christiansen et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
The calcium-sensing receptor and its interacting proteins
Chunfa Huang et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2007)
Parathyroid-specific double knockout of G(q) and G(11) alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+-sensing receptor
Nina Wettschureck et al.
MOLECULAR ENDOCRINOLOGY (2007)
Broad-spectrum L-amino acid sensing by class 3 G-protein-coupled receptors
Arthur D. Conigrave et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2006)
Long-term treatment of secondary hyperparathyroidism with the calcimimetic cinacalcet HCl
SM Moe et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2005)
Calcium-sensing receptor gene transcription is up-regulated by the proinflammatory cytokine, interleukin-1β -: Role of the NF-κB pathway and κB elements
L Canaff et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism
M Colloton et al.
KIDNEY INTERNATIONAL (2005)
Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism
M Peacock et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)
Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones
MM Dvorak et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Diseases associated with the extracellular calcium-sensing receptor
RV Thakker
CELL CALCIUM (2004)
Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl
EF Nemeth et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification
TA Hough et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
L-amino acids regulate parathyroid hormone secretion
AD Conigrave et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Functional deletion of the calcium-sensing receptor in a case of neonatal severe hyperparathyroidism
BK Ward et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2004)
Brief report - Acquired hypocalciuric hypercalcemia due to autoantibodies against the calcium-sensing receptor
JC Pallais et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Calcium-sensing receptor regulation of PTH-inhibitable proximal tubule phosphate transport
JM Ba et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2003)
Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells
J Tfelt-Hansen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2003)
Autosomal dominant hypocalcemia: A novel activating mutation (E604K) in the cysteine-rich domain of the calcium-sensing receptor
YM Tan et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)
A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor
O Kifor et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)
Protein kinase C (PKC) phosphorylation of the Ca2+-sensing receptor (CaR) modulates functional interaction of g proteins with the CaR cytoplasmic tail
YF Jiang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
L-amino acid sensing by the calcium-sensing receptor: a general mechanism for coupling protein and calcium metabolism?
AD Conigrave et al.
EUROPEAN JOURNAL OF CLINICAL NUTRITION (2002)
Human calcium-sensing receptor gene - Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D
L Canaff et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Evidence for distinct cation and calcimimetic compound (NPS 568) recognition domains in the transmembrane regions of the human Ca2+ receptor
K Ray et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+
D Tsuchiya et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Heterodimerization of calcium sensing receptors with metabotropic glutamate receptors in neurons
L Gama et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Dietary phosphate and parathyroid hormone alter the expression of the calcium-sensing receptor (CaR) and the Na+-dependent Pi transporter [NaPi-2) in the rat proximal tubule
D Riccardi et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2000)
Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor
N Kunishima et al.
NATURE (2000)
Cooperative multi-modal sensing and therapeutic implications of the extracellular Ca2+-sensing receptor
AD Conigrave et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2000)
L-Amino acid sensing by the extracellular Ca2+-sensing receptor
AD Conigrave et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Risk factors for postoperative hypocalcemia after surgery for primary hyperparathyroidism
J Westerdahl et al.
ARCHIVES OF SURGERY (2000)
Share Paper
