Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 100, Pages 13935-13938Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc05905c
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Funding
- NationalNatural Science Foundation of China [22061044, 21871228]
- Natural Science Foundation of Yunnan Province [202001BB050038, 202201AT070205]
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A visible-light-induced radical cascade reaction was developed for the direct alkynylation of tryptamines with alkynyl sulfones, resulting in a series of high-yield C3-alkynyl pyrroloindolines. This method offers readily available substrates, good functional group tolerability, and scalability. C3-alkynyl pyrroloindolines show great potential as useful building blocks in the preparation of complex and valuable pyrroloindoline alkaloids.
A visible-light-induced radical cascade reaction for the direct alkynylation of tryptamines with alkynyl sulfones was developed, affording a series of C3-alkynyl pyrroloindolines in excellent yields. This method features readily available substrates, good functional group tolerability, and scalability. C3-alkynyl pyrroloindolines show great potential as useful building blocks in the preparation of complex and valuable pyrroloindoline alkaloids.
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