Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 100, Pages 13911-13914Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc05848k
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Funding
- National Natural Science Foundation of China [21973071, 21773178, 21573168]
- Natural Science Foundation of Tianjin [21JCQNJC01450, 21JCQNJC01470]
- Science and Technology Plans of Tianjin [22ZYJDSS00070, 21ZYJDJC00050]
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The study designed and constructed competitive, noncompetitive, and uncompetitive inhibitors using enzymes with different surface charges and gold nanoparticles with different surface ligands and particle sizes. It is the first time that an uncompetitive nano inhibitor has been discovered.
Three common types of reversible inhibitors, namely competitive, noncompetitive and uncompetitive inhibitors, were designed and constructed by using enzymes with different surface charges and gold nanoparticles with different surface ligands and particle sizes. To our knowledge, it is the first time that an uncompetitive nano inhibitor has been discovered.
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