☆ 4.7 Article

Organophosphorus Flame Retardant TCPP Induces Cellular Senescence in Normal Human Skin Keratinocytes: Implication for Skin Aging

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Related references

Note: Only part of the references are listed.

Review Cell Biology

Histone H2A variants: Diversifying chromatin to ensure genome integrity

Philipp Oberdoerffer et al.

Summary: Histone variants, such as H2A.X, H2A.Z, and macroH2A, play crucial roles in protecting the integrity of the genome through DNA damage response pathways. Their deposition, posttranslational modifications, and interactions with other proteins safeguard DNA from both endogenous and exogenous threats. Understanding the involvement of H2A variants in maintaining genome stability and their contributions to human diseases, including cancer, provides valuable insights.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2023)

Add to Collection

Article Environmental Sciences

Effects of soil-extractable metals Cd and Ni from an e-waste dismantling site on human colonic epithelial cells Caco-2: Mechanisms and implications

Jiao-Yang Ma et al.

Summary: This study assessed the toxic effects and underlying mechanisms of toxic metals released from e-wastes on human colonic epithelial cells. The findings revealed that the soil extracts induced cytotoxicity, oxidative damage, inflammatory response, and cell apoptosis. These results suggest that soil ingestion from e-waste dismantling sites may adversely impact human health.

CHEMOSPHERE (2022)

Add to Collection

Article Environmental Sciences

Dermal uptake of chlorinated organophosphate flame retardants via contact with furniture fabrics; implications for human exposure

Mohamed Abou-Elwafa Abdallah et al.

Summary: The chlorinated organophosphate flame retardants (Cl-PFRs) have been widely used in upholstered furniture despite their carcinogenic potential. This study assessed the dermal absorption of these chemicals from furniture fabrics for the first time, revealing that all three target Cl-PFRs were dermally bioavailable to varying degrees. Factors such as compound properties, exposure matrix, exposure dose, and skin hydration can influence the dermal uptake of Cl-PFRs.

ENVIRONMENTAL RESEARCH (2022)

Add to Collection

Article Environmental Sciences

Polybrominated diphenyl ether quinone exposure leads to ROS-driven lysosomal damage, mitochondrial dysfunction and NLRP3 inflammasome activation

Bingwei Yang et al.

Summary: Exposure to PBDEs metabolite PBDEQ induces ROS and mitochondrial dysfunction, promoting NLRP3 inflammasome activation through the TLRs-NF-kappa B signaling pathway. Additionally, bromine metabolism and K+ efflux are involved in the activation of this inflammatory response.

ENVIRONMENTAL POLLUTION (2022)

Add to Collection

Article Environmental Sciences

BDE-209 and DBDPE induce male reproductive toxicity through telomere-related cell senescence and apoptosis in SD rat

Xiangyang Li et al.

Summary: This study found that both BDE-209 and DBDPE can cause testicular damage, decrease sperm quantity and motility, increase sperm malformation rates, and induce cell senescence and apoptosis in rat testis by shortening telomere length and reducing telomerase activity. BDE-209 had more severe effects on male reproduction compared to DBDPE.

ENVIRONMENT INTERNATIONAL (2021)

Add to Collection

Review Genetics & Heredity

Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair

Nazanin Rahmanian et al.

Summary: The phosphorylation of histone variant H2AX and the formation of gamma H2AX are primary responses to DNA double-strand breaks, serving as robust and sensitive tools for diagnosing DNA damage and repair in pre-clinical drug discovery investigations. Gamma H2AX can also serve as a surrogate marker for drug-induced cytotoxicity, while recent advances in genomic research allow for its detection as a specific biomarker for quantitatively analyzing DNA damages and repair. The use of gamma H2AX as a biomarker shows promise in genotoxicity analyses and the monitoring and management of cancer diseases.

DNA REPAIR (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Mechanisms and Regulation of Cellular Senescence

Laureline Roger et al.

Summary: Cellular senescence is an essentially irreversible proliferative arrest state where cells release pro-inflammatory and proteolytic factors. Different types of senescent cells accumulate in various tissues and organs with unique functions. Understanding how cells undergo extensive changes to induce a common cellular state is crucial for cancer prevention and improving health during aging.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Orthopedics

Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell-Derived Exosomes on the Senescence of Nucleus Pulposus Cells

Chang-chun Chen et al.

Summary: The study found that SNPC-Exo treatment can induce NPC senescence, while inhibition of the P53/P21 pathway can attenuate SNPC-Exo-induced NPC senescence. Inhibition of the P53/P21 pathway led to an increase in NPC proliferation rate, a decrease in the percentage of SA-beta-gal-positive cells, and facilitated NPC entry into the S phase.

ORTHOPAEDIC SURGERY (2021)

Add to Collection

Review Dermatology

Environmentally-Induced (Extrinsic) Skin Aging: Exposomal Factors and Underlying Mechanisms

Jean Krutmann et al.

Summary: The skin, as a barrier organ, is an ideal model for studying environmentally-induced aging. This review explains how exposure to specific exposomal factors can lead to extrinsic skin aging, involving interactions between these factors and genetic modifications, ultimately causing macromolecular damage and changes in fibroblasts in the dermal compartment of the skin.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

Add to Collection

Review Cell Biology

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Ruchi Kumari et al.

Summary: Cellular senescence is a stable cell cycle arrest triggered in response to various stimuli, characterized by dynamic changes in senescent cells. It has both positive effects on tissue repair and anti-cancer mechanisms, but can also negatively impact organismal health. Multiple pathways, including p53/p21 and p16/pRB, play central roles in regulating this process.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection

Article Pharmacology & Pharmacy

Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells

Zixuan Liu et al.

Summary: The study demonstrated that PBDEQ exposure could induce DNA damage, cell apoptosis, and G2/M phase cell arrest in a p53-dependent manner. Activation of p53 coordinated cell cycle progression, alleviated DNA damage, and ultimately mitigated apoptosis in BV2 cells. Antioxidant NAC inhibited p53 activation upon PBDEQ exposure, suggesting that PBDEQ-induced DNA damage and p53 activation were mediated by reactive oxygen species (ROS).

TOXICOLOGY (2021)

Add to Collection

Article Toxicology

p53-mediated ferroptosis is required for 1-methyl-4-phenylpyridinium-in-duced senescence of PC12 cells

Shanshan Li et al.

Summary: The study found that ferroptosis associated with Parkinson's disease may accelerate the disease progression by promoting cellular senescence, and the use of an ferroptosis inhibitor can eliminate cellular senescence.

TOXICOLOGY IN VITRO (2021)

Add to Collection

Article Environmental Sciences

Organophosphorus flame retardants in breast milk from Beijing, China: Occurrence, nursing infant's exposure and risk assessment

Xuelei Chen et al.

Summary: The study investigated the occurrence of thirteen OPFRs in breast milk samples collected from Beijing mothers in 2018, revealing China as one of the most affected regions by OPFRs. Personal characteristics of mothers were found to impact the levels of certain OPFRs in breast milk, with most nursing infants' daily OPFR intake not raising significant health concerns. However, two OPFRs, TPhP and EHDPP, were noted to have higher estimated daily intakes than corresponding reference doses, potentially posing health risks.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Add to Collection

Article Environmental Sciences

Organophosphate esters in human serum in Bohai Bay, North China

Dute Gao et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2020)

Add to Collection

Article Cell Biology

Aging of the cells: Insight into cellular senescence and detection Methods

Nor Shaheera Mohamad Kamal et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2020)

Add to Collection

Article Environmental Sciences

Organophosphorus flame retardant TDCPP-induced cytotoxicity and associated mechanisms in normal human skin keratinocytes

Daolei Cui et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Add to Collection

Article Cell Biology

PIK3R3 inhibits cell senescence through p53/p21 signaling

Qianzhi Chen et al.

CELL DEATH & DISEASE (2020)

Add to Collection

Review Cell Biology

Senescence and the SASP: many therapeutic avenues

Jodie Birch et al.

GENES & DEVELOPMENT (2020)

Add to Collection

Article Oncology

Negative Regulation of p53-Induced Senescence by N-WASP Is Crucial for DMBA/TPA-Induced Skin Tumor Formation

Hui Li et al.

CANCER RESEARCH (2019)

Add to Collection

Article Environmental Sciences

Organophosphate esters in house dust: A comparative study between Canada, Turkey and Egypt

Tamer Shoeib et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2019)

Add to Collection

Review Physiology

CELLULAR SENESCENCE: AGING, CANCER, AND INJURY

Arianna Calcinotto et al.

PHYSIOLOGICAL REVIEWS (2019)

Add to Collection

Review Oncology

The Role of the Cyclin Dependent Kinase Inhibitor p21cip1/waf1 in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics

Samar Al Bitar et al.

CANCERS (2019)

Add to Collection

Review Geriatrics & Gerontology

Regulation of senescence and the SASP by the transcription factor C/EBPβ

Jacqueline Salotti et al.

EXPERIMENTAL GERONTOLOGY (2019)

Add to Collection

Article Medicine, Research & Experimental

4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer

Zhicong Zhao et al.

LIFE SCIENCES (2019)

Add to Collection

Article Toxicology

Effects of tris(1-chloro-2-propyl)phosphate and tris(2-chloroethyl)phosphate on cell viability and morphological changes in peripheral blood mononuclear cells (in vitro study)

K. Mokra et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2018)

Add to Collection

Article Environmental Sciences

Urinary metabolites of organophosphate flame retardants in 0-5-year-old children: Potential exposure risk for inpatients and home stay infants

Bo Zhang et al.

ENVIRONMENTAL POLLUTION (2018)

Add to Collection

Article Oncology

Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects

Qianqian He et al.

ONCOGENESIS (2018)

Add to Collection

Review Genetics & Heredity

Biomarkers of Cellular Senescence and Skin Aging

Audrey S. Wang et al.

FRONTIERS IN GENETICS (2018)

Add to Collection

Article Environmental Sciences

Tris (2-chloroethyl) phosphate induces senescence-like phenotype of hepatocytes via the p21Waf1/Cip1-Rb pathway in a p53-independent manner

Wenjuan Zhang et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Cellular senescence regulated by SWI/SNF complex subunits through p53/p21 and p16/pRB pathway

Ling He et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2017)

Add to Collection

Review Dermatology

The skin aging exposome

Jean Krutmann et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2017)

Add to Collection

Article Medicine, Research & Experimental

p53 in the DNA-Damage-Repair Process

Ashley B. Williams et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)

Add to Collection

Article Immunology

Environmental Pollutant Polybrominated Diphenyl Ether, a Flame Retardant, Induces Primary Amnion Cell Senescence

Faranak Behnia et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2015)

Add to Collection

Review Environmental Sciences

Evaluation of in vitro vs. in vivo methods for assessment of dermal absorption of organic flame retardants: A review

Mohamed Abou-Elwafa Abdallah et al.

ENVIRONMENT INTERNATIONAL (2015)

Add to Collection

Article Engineering, Environmental

High Exposure to Organophosphate Flame Retardants in Infants: Associations with Baby Products

Kate Hoffman et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions

Valentina Turinetto et al.

NUCLEIC ACIDS RESEARCH (2015)

Add to Collection

Article Food Science & Technology

MEHP-induced oxidative DNA damage and apoptosis in HepG2 cells correlates with p53-mediated mitochondria-dependent signaling pathway

Guangtao Yang et al.

FOOD AND CHEMICAL TOXICOLOGY (2012)

Add to Collection

Review Behavioral Sciences

Human threat management systems: Self-protection and disease avoidance

Steven L. Neuberg et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2011)

Add to Collection

Article Biochemical Research Methods

Protocols to detect senescence-associated beta-galactosidase (SA-beta gal) activity, a biomarker of senescent cells in culture and in vivo

Florence Debacq-Chainiaux et al.

NATURE PROTOCOLS (2009)

Add to Collection

Article Geriatrics & Gerontology

Aged keratinocyte phenotyping: Morphology, biochemical markers and effects of Dead Sea minerals

Yoram Soroka et al.

EXPERIMENTAL GERONTOLOGY (2008)

Add to Collection

© Peeref 2019-2024. All rights reserved.