Journal
EUROPEAN JOURNAL OF PEDIATRICS
Volume -, Issue -, Pages -Publisher
SPRINGER
DOI: 10.1007/s00431-022-04719-x
Keywords
Kawasaki disease; Coronary artery aneurysm; Coronary events; Major adverse cardiac events; Warfarin
Categories
Funding
- Japan Agency for Medical Research and Development (AMED) [JP20ek0109467]
- Tokyo Metropolitan Government Hospitals
- Japanese Society of Kawasaki Disease
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This multicenter registry study aimed to investigate the long-term prognosis and associated factors of patients with Kawasaki disease complicated by coronary artery aneurysms. The study found that the presence of large coronary artery aneurysms is an important factor for coronary events in these patients.
The long-term prognosis of patients with Kawasaki disease (KD) complicated by coronary artery aneurysms (CAA) is still unclear. The present, multicenter registry study aimed to study the factors associated with coronary events (CE) and determine an appropriate management method for patients with KD complicated with CAA. Patients with KD with onset after 2015 and with a medium-sized or large CAA having an actual diameter >= 4 mm or a Z-score >= 5.0 at 30 days and later after KD onset were included in the annual survey. The primary endpoint was the time-dependent incidence of CE. Associated factors were also examined. In total, 179 patients from 53 centers were enrolled and followed up for a median of 501 days. The median age at KD onset was 2.2 years, 137 patients were male (77%), 47 had incomplete KD (26%), and 36 had large CAA (20%). CE occurred in 13 patients (7%; 95% confidence interval: 4-12%); eight (62%) experienced CE within 1 year, and all the patients experienced a CE within 2 years. All but one patient received antiplatelet drugs and warfarin. Patients with a large CAA had significantly more CAA (2.8 vs. 1.7, p < 0.001), more cases of warfarin use (86% vs. 43%, p < 0.001), and were more likely to have CE (28% vs. 2%, p < 0.001) than those with a medium-sized CAA. On univariate Cox regression analysis, the factors significantly associated with CE were large CAA (hazard ratio (HR): 17.0), three or more CAA (HR: 23.3), and beaded CAA (HR: 15.9). Multivariable Cox regression analysis revealed that the only associated factor was a large CAA. Conclusion: Patients with a large CAA were more likely to have a CE within 2 years. Antithrombotic therapy with warfarin did not eliminate the CE risk, and better therapies are desirable.
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