Journal
FRONTIERS IN NEUROSCIENCE
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2016.00031
Keywords
Alzheimer's disease (AD); Amyloid-beta oligomers (A beta Os); neurofibrillary tangles (NFTs); tau phosphorylation; synaptic dysfunction
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Funding
- Owens Family Foundation
- Alzheimer's Association
- Cure Alzheimer's Fund
- NIH [1F31NS09244401A1]
- University of Virginia's President's Fund for Excellence
- Webb and Tate Wilson and the Fraternal Order of Eagles
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Tau is a microtubule-associated protein whose misfolding, hyper-phosphorylation, loss of normal function and toxic gain of function are linked to several neurodegenerative disorders, including Alzheimer's disease (AD). This review discusses the role of tau in amyloid-beta (A beta) induced toxicity in AD. The consequences of tau dysfunction, starting from the axon and concluding at somadendritic compartments, will be highlighted.
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