3.8 Article

Mild pentachlorophenol-mediated uncoupling of mitochondria depletes ATP but does not cause an oxidized redox state or dopaminergic neurodegeneration in Caenorhabditis elegans

Related references

Note: Only part of the references are listed.
Article Cell Biology

Sex- and strain-specific effects of mitochondrial uncoupling on age-related metabolic diseases in high-fat diet-fed mice

Leigh Goedeke et al.

Summary: Mild mitochondrial uncoupling has potential as an anti-aging therapy, but chronic ingestion of uncouplers has unwanted side effects. A controlled-release mitochondrial protonophore (CRMP) was developed and tested in aged high-fat diet-fed mice. The results showed that CRMP reduced hepatic lipid content, improved insulin resistance, and protected against neoplastic disorders, demonstrating the potential of liver-directed mitochondrial uncouplers in promoting healthy aging.

AGING CELL (2022)

Article Environmental Sciences

Pentachlorophenol exposure in early pregnancy and gestational diabetes mellitus: A nested case-control study

Yitao Huo et al.

Summary: This study found that pregnant women in central China are widely exposed to pentachlorophenol (PCP) in the environment. The study also reports for the first time that PCP exposure may increase the risk of gestational diabetes mellitus (GDM), with potential effect modifications by maternal age and fetal sex.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

Review Neurosciences

Mitochondria and Parkinson's Disease: Clinical, Molecular, and Translational Aspects

Max Borsche et al.

Summary: Mitochondrial dysfunction plays a critical role in the pathogenesis of Parkinson's disease, with genetic and idiopathic PD studies supporting its contribution. Some PD patients carry genetic alterations related to mitochondrial function, highlighting the importance of mitochondrial pathways in PD. Therefore, therapeutic approaches targeting mitochondrial dysfunction may hold potential in preventing or delaying neurodegeneration in PD.

JOURNAL OF PARKINSONS DISEASE (2021)

Article Toxicology

Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors

Johannes Delp et al.

Summary: The study utilized 21 pesticides described as mitochondrial inhibitors to investigate the adverse outcome pathway (AOP:3) of Parkinson's disease, finding that some inhibitors triggered neurodegeneration while others did not. There was a clear hierarchy of assay sensitivity, with mitochondrial failure being much more sensitive than neurite damage in predicting toxic reactions.

ARCHIVES OF TOXICOLOGY (2021)

Review Environmental Sciences

Xenobiotic metabolism and transport in Caenorhabditis elegans

Jessica H. Hartman et al.

Summary: Caenorhabditis elegans has become a major model in biomedical and environmental toxicology, attracting research interest in various fields. However, the study of xenobiotic metabolism and transport processes in C. elegans remains underdeveloped. This review summarizes the history of C. elegans in toxicological and pharmacological studies, physical barriers to chemical uptake, and known and unknown processes of xenobiotic metabolism.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2021)

Article Multidisciplinary Sciences

Quantifying Levels of Dopaminergic Neuron Morphological Alteration and Degeneration in Caenorhabditis elegans

Shefali R. Bijwadia et al.

Summary: Many details of Parkinson's Disease etiology are still unknown, necessitating studies on genetic and environmental contributors to discover methods of prevention, management, and treatment. Proper characterization of dopaminergic neuronal loss is relevant not only to PD research, but also to other prevalent neurodegenerative disorders.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2021)

Article Environmental Sciences

Pentachlorophenol and nine other chlorophenols in urine of children and adolescents in Germany - Human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V)

Maria I. H. Schmied-Tobies et al.

Summary: Chlorophenols are a group of chemicals widely used in the production of biocides, pharmaceuticals, and other industrial products due to their biocidal properties. Some chlorophenols are toxic to aquatic life and harmful to humans, possibly causing cancer. A study in Germany from 2014 to 2017 found relatively low levels of chlorophenol exposure in children and adolescents, with levels lower than those found in North America.

ENVIRONMENTAL RESEARCH (2021)

Article Environmental Sciences

AOP Report: Uncoupling of Oxidative Phosphorylation Leading to Growth Inhibition via Decreased Cell Proliferation

You Song et al.

Summary: This report describes a novel adverse outcome pathway (AOP) on uncoupling of oxidative phosphorylation (OXPHOS) leading to growth inhibition via decreased adenosine triphosphate (ATP) pool and cell proliferation. The proposed key events in this AOP can be measured using in vitro high-throughput bioassays, and growth inhibition can also be measured in a high-throughput format using standard in vivo toxicity test protocols. The AOP is considered highly relevant and applicable to both human health and ecological risk assessments.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2021)

Article Toxicology

Development of a neurotoxicity assay that is tuned to detect mitochondrial toxicants

Johannes Delp et al.

ARCHIVES OF TOXICOLOGY (2019)

Article Biochemistry & Molecular Biology

Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration

Jessica H. Hartman et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Chemistry, Medicinal

Development of a Decision Tree for Mitochondrial Dysfunction: Uncoupling of Oxidative Phosphorylation

Steven J. Enoch et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2018)

Review Biochemistry & Molecular Biology

Determinants of dopaminergic neuron loss in Parkinson's disease

Dalton James Surmeier

FEBS JOURNAL (2018)

Review Toxicology

Mitochondrial Toxicity

Joel N. Meyer et al.

TOXICOLOGICAL SCIENCES (2018)

Article Multidisciplinary Sciences

Comparative metabolism of xenobiotic chemicals by cytochrome P450s in the nematode Caenorhabditis elegans

Philippa H. Harlow et al.

SCIENTIFIC REPORTS (2018)

Article Clinical Neurology

DNP, mitochondrial uncoupling, and neuroprotection: A little dab'll do ya

John G. Geisler et al.

ALZHEIMERS & DEMENTIA (2017)

Review Pharmacology & Pharmacy

Adverse Outcome Pathways-Organizing Toxicological Information to Improve Decision Making

Stephen W. Edwards et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)

Article Public, Environmental & Occupational Health

Predictors of urinary levels of 2,4-dichlorophenoxyacetic acid, 3,5,6-trichloro-2-pyridinol, 3-phenoxybenzoic acid, and pentachlorophenol in 121 adults in Ohio

Marsha K. Morgan

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH (2015)

Article Environmental Sciences

Short-Term Variability and Predictors of Urinary Pentachlorophenol Levels in Ohio Preschool Children

Marsha Morgan et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2015)

Editorial Material Biochemistry & Molecular Biology

Mitochondrial toxicity assessment in industry - a decade of technology development and insight

Yvonne Will et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2014)

Article Multidisciplinary Sciences

Exposure to Mitochondrial Genotoxins and Dopaminergic Neurodegeneration in Caenorhabditis elegans

Claudia P. Gonzalez-Hunt et al.

PLOS ONE (2014)

Article Pharmacology & Pharmacy

Pentachlorophenol exposure causes Warburg-like effects in zebrafish embryos at gastrulation stage

Ting Xu et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2014)

Article Chemistry, Medicinal

Systematic Study of Mitochondria! Toxicity of Environmental Chemicals Using Quantitative High Throughput Screening

Matias S. Attene-Ramos et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2013)

Article Multidisciplinary Sciences

WormSizer: High-throughput Analysis of Nematode Size and Shape

Brad T. Moore et al.

PLOS ONE (2013)

Review Toxicology

Mitochondria as a Target of Environmental Toxicants

Joel N. Meyer et al.

TOXICOLOGICAL SCIENCES (2013)

Article Biochemistry & Molecular Biology

Exploring real-time in vivo redox biology of developing and aging Caenorhabditis elegans

Patricia Back et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Review Biochemistry & Molecular Biology

Assessing mitochondrial dysfunction in cells

Martin D. Brand et al.

BIOCHEMICAL JOURNAL (2011)

Article Biochemistry & Molecular Biology

Mitochondrial ('mild') uncoupling and ROS production: physiologically relevant or not?

Irina G. Shabalina et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2011)

Article Marine & Freshwater Biology

Intracellular uptake and associated toxicity of silver nanoparticles in Caenorhabditis elegans

Joel N. Meyer et al.

AQUATIC TOXICOLOGY (2010)

Article Pharmacology & Pharmacy

Investigating Drug-induced Mitochondrial Toxicity: A Biosensor to Increase Drug Safety?

Claudia V. Pereira et al.

CURRENT DRUG SAFETY (2009)

Review Biochemistry & Molecular Biology

Mitochondrial H+ leak and ROS generation: An odd couple

PS Brookes

FREE RADICAL BIOLOGY AND MEDICINE (2005)

Review Medicine, General & Internal

Parkinson's disease

A Samii et al.

LANCET (2004)

Article Biochemistry & Molecular Biology

Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators

CT Dooley et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma

G Mattiasson et al.

NATURE MEDICINE (2003)

Article Biochemistry & Molecular Biology

Characterization of metabolic activation of pentachlorophenol to quinones and semiquinones in rodent liver

CH Tsai et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2001)

Article Environmental Sciences

Standardized growth toxicity testing (Cu, Zn, Ph, and pentachlorophenol) with Helix aspersa

A Gomot-De Vaufleury

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2000)