Journal
FRONTIERS IN ONCOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.1050274
Keywords
chronic pancreatitis; anti-inflammatory agents; fibrosis; therapeutics; mesenchymal stem cell; phytochemicals
Categories
Funding
- National Natural Science Foundation of China
- 2021Shandong Province Graduate Education and Teaching Reform Research Project
- Qingdao Chinese Medicine Technology Project
- [82270676]
- [SDYJG21110]
- [2021-zyym26]
Ask authors/readers for more resources
This article reviews the pathogenesis of chronic pancreatitis (CP) and the research progress on anti-inflammatory and anti-fibrotic therapies. Currently, clinical treatment of CP is mainly symptomatic and lacks effective etiological treatment. However, experiments have shown that some active substances have great potential in the etiological treatment of chronic pancreatitis.
Chronic pancreatitis (CP) is a chronic progressive inflammatory disease of the pancreas, caused by multiple factors and accompanied by irreversible impairment of pancreatic internal and external secretory functions. Pathologically, atrophy of the pancreatic acini, tissue fibrosis or calcification, focal edema, inflammation, and necrosis are observed. Clinical manifestations include recurrent or persistent abdominal pain, diarrhea, emaciation, and diabetes. In addition, CP is prone to develop into pancreatic cancer(PC) due to persistent inflammation and fibrosis. The disease course is prolonged and the clinical prognosis is poor. Currently, clinical treatment of CP is still based on symptomatic treatment and there is a lack of effective etiological treatment. Encouragingly, experiments have shown that a variety of active substances have great potential in the etiological treatment of chronic pancreatitis. In this paper, we will review the pathogenesis of CP, as well as the research progress on anti-inflammatory and anti-fibrotic therapies, which will provide new ideas for the development of subsequent clinical studies and formulation of effective treatment programs, and help prevent CP from developing into pancreatic cancer and reduce the prevalence of PC as much as possible.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available