Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 97, Pages 13475-13478Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc05251b
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Funding
- National Natural Science Foundation of China [81672570]
- State Key Laboratory of Natural and Biomimetic Drugs [K202009]
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In this study, a simple method using a functional RNA/DNA circuit is proposed for the detection of SARS-CoV-2 RNA. By integrating nucleic acid circuit technology and CRISPR/cas12a system, this method can achieve femtomolar detection of the target RNA in one step and successfully distinguish COVID-19 positive cases from clinical samples, demonstrating its great potential for clinical application.
A simple method is proposed in this work for the detection of SARS-CoV-2 RNA based on a functional RNA/DNA circuit. By ingeniously integrating the nucleic acid circuit technology and CRISPR/cas12a system, this method can achieve femtomolar detection of the target RNA in one step and successfully distinguish COVID-19 positive cases from clinical samples, proving its great potential for clinical application.
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