4.7 Article

Breast cancer metastasis: Is it a matter of OMICS and proper ex-vivo models?

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients

Bastien Nguyen et al.

Summary: This study investigates the genomic mechanisms driving metastasis in cancer patients. By analyzing a cohort of over 25,000 patients with metastatic diseases, the researchers identify associations between genomic alterations and patterns of metastatic dissemination across different tumor types. The study highlights the complex role of chromosomal instability in cancer progression and provides valuable insights for further research on metastatic spread.
Review Biochemistry & Molecular Biology

The Epithelial-Mesenchymal Transition at the Crossroads between Metabolism and Tumor Progression

Monica Fedele et al.

Summary: The transition between epithelial and mesenchymal phenotype plays a key role in tumor cell invasion and metastasis. This process, known as epithelial-mesenchymal transition (EMT) and its reverse process called mesenchymal-epithelial transition (MET), is closely associated with metabolic changes and successful cancer progression. This review focuses on the complex interaction between EMT and metabolism during tumor progression, with a particular emphasis on cancer stem cells and Long non-coding RNAs (LncRNAs). Specific cancers such as breast, lung, and thyroid cancer are also discussed.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Cell Biology

Integrated single-cell multiomics analysis reveals novel candidate markers for prognosis in human pancreatic ductal adenocarcinoma

Xiaoying Fan et al.

Summary: This study used single-cell multiomics sequencing to uncover the epigenomic abnormality of pancreatic ductal adenocarcinoma (PDAC). The findings revealed differential DNA methylation and chromatin accessibility in cancer cells compared to normal epithelial cells, and identified novel candidate biomarkers associated with prognosis in PDAC patients.

CELL DISCOVERY (2022)

Article Oncology

INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors

Qing Li et al.

Summary: This study identifies CDK4/6 kinase activation as a common mechanism in oncogenic signaling-induced proliferation and develops a new strategy for inhibiting CDK4/6 kinases to overcome resistance.

CANCER DISCOVERY (2022)

Review Biochemistry & Molecular Biology

How a cell decides its own fate: a single-cell view of molecular mechanisms and dynamics of cell-type specification

Maria Mircea et al.

Summary: During the process of development, cells transition from a fertilized egg to various cell types within multicellular organisms, with this transformation being driven by the interplay of external signals, internal cellular states, and complex molecular machinery; single-cell omics techniques are providing a comprehensive view of molecular changes during cell-type specification and have the potential to uncover gene regulatory mechanisms.

BIOCHEMICAL SOCIETY TRANSACTIONS (2021)

Article Oncology

A Phase I Study of Alpelisib in Combination with Trastuzumab and LJM716 in Patients with PIK3CA-Mutated HER2-Positive Metastatic Breast Cancer

Komal Jhaveri et al.

Summary: The study found that combination treatment with alpelisib, trastuzumab, and LJM716 in PIK3CA-mutant HER2-positive metastatic breast cancer showed some efficacy, but was limited by gastrointestinal toxicity. Further efforts are needed to target the PI3K pathway in HER2(+) MBC.

CLINICAL CANCER RESEARCH (2021)

Review Oncology

Phenotypic Heterogeneity of Triple-Negative Breast Cancer Mediated by Epithelial-Mesenchymal Plasticity

Barbora Kvokackova et al.

Summary: Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) play critical roles in the development of TNBC, shaping aggressive and heterogeneous biological features, but may also contribute to the progression of metastatic disease.

CANCERS (2021)

Review Oncology

Breast cancer brain metastasis: insight into molecular mechanisms and therapeutic strategies

Yajie Wang et al.

Summary: Breast cancer brain metastasis is a common cause of death among breast cancer patients, with poor prognosis due to limited permeability of the blood-brain barrier and lack of effective treatments. While the sequence of metastasis events is accepted, the underlying mechanisms remain to be fully elucidated.

BRITISH JOURNAL OF CANCER (2021)

Article Oncology

Genomic and Transcriptomic Analyses of Breast Cancer Primaries and Matched Metastases in AURORA, the Breast International Group (BIG) Molecular Screening Initiative

Philippe Aftimos et al.

Summary: The AURORA program conducted genomic and transcriptomic analyses on matched primary and metastatic samples from 381 breast cancer patients, identifying genomic alterations enriched in metastases and prognostic biomarkers. Over half of the patients had ESCAT tier I/II alterations detected.

CANCER DISCOVERY (2021)

Article Biochemistry & Molecular Biology

HUNK phosphorylates EGFR to regulate breast cancer metastasis

Carly B. Williams et al.

ONCOGENE (2020)

Review Oncology

Current concepts in tumour-derived organoids

Ross J. Porter et al.

BRITISH JOURNAL OF CANCER (2020)

Article Multidisciplinary Sciences

Genomic characterization of metastatic breast cancers

Francois Bertucci et al.

NATURE (2019)

Review Multidisciplinary Sciences

Cancer modeling meets human organoid technology

David Tuveson et al.

SCIENCE (2019)

Article Medicine, General & Internal

Multi-Omics Characterization of the Spontaneous Mesenchymal-Epithelial Transition in the PMC42 Breast Cancer Cell Lines

Sugandha Bhatia et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Review Oncology

Metabolic crosstalk in the breast cancer microenvironment

Ana S. Dias et al.

EUROPEAN JOURNAL OF CANCER (2019)

Review Endocrinology & Metabolism

Crosstalk between Estrogen Signaling and Breast Cancer Metabolism

Eylem Kulkoyluoglu-Cotul et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)

Article Biochemistry & Molecular Biology

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

Norman Sachs et al.

Review Cell & Tissue Engineering

Concise Review: Current Status of Three-Dimensional Organoids as Preclinical Models

Garima Kaushik et al.

STEM CELLS (2018)

Article Oncology

The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers

Pedram Razavi et al.

CANCER CELL (2018)

Article Oncology

Metabolic advantages and vulnerabilities in brain metastases

Alexandra K. Ciminera et al.

CLINICAL & EXPERIMENTAL METASTASIS (2017)

Article Oncology

Genomic Evolution of Breast Cancer Metastasis and Relapse

Lucy R. Yates et al.

CANCER CELL (2017)

Article Oncology

Comparative clinical utility of tumor genomic testing and cell-free DNA in metastatic breast cancer

Kara N. Maxwell et al.

BREAST CANCER RESEARCH AND TREATMENT (2017)

Article Medicine, General & Internal

Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis

Celine Lefebvre et al.

PLOS MEDICINE (2016)

Article Biochemistry & Molecular Biology

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

Giovanni Ciriello et al.

Article Multidisciplinary Sciences

Human breast cancer metastases to the brain display GABAergic properties in the neural niche

Josh Neman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Medicine, General & Internal

Panitumumab-FOLFOX4 Treatment and RAS Mutations in Colorectal Cancer

Jean-Yves Douillard et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Oncology

Frequent Mutational Activation of the PI3K-AKT Pathway in Trastuzumab-Resistant Breast Cancer

Sarat Chandarlapaty et al.

CLINICAL CANCER RESEARCH (2012)

Article Medicine, General & Internal

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

Paul B. Chapman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Review Oncology

Signaling pathways in breast cancer metastasis - novel insights from functional genomics

Mario Andres Blanco et al.

BREAST CANCER RESEARCH (2011)

Article Oncology

Adaptation of energy metabolism in breast cancer brain metastases

Emily I. Chen et al.

CANCER RESEARCH (2007)