Journal
FEBS OPEN BIO
Volume 6, Issue 6, Pages 548-557Publisher
WILEY-BLACKWELL
DOI: 10.1002/2211-5463.12062
Keywords
dendritic cells; sheep red blood cells; T-cell dependent antigen response; transforming growth factor-beta-activated kinase 1
Categories
Funding
- National Sciences Foundations of the People's Republic of China [81273112]
Ask authors/readers for more resources
Dendritic cells (DCs) are important in the initiation of primary T-cell responses, while transforming growth factor-beta (TGF-beta)-activated kinase 1 (TAK1) is a critical regulator of DC survival and homeostasis. This study evaluated the T-cell dependent antibody response (TDAR) to sheep red blood cells (SRBC) on a DC-specific TAK1-deficient mice model. The results showed that TAK1 deficiency in DCs significantly suppressed the humoral and cellular immune response in mice. DC-specific TAK1 deletion impaired splenic T-cell population and conventional DCs, abolished the cytokine production of splenic T cells and down-regulated some functional gene expression in the spleen. Collectively, this study suggests that TAK1 plays an essential role in the development of the humoral immune response.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available