Emerging current trends and research focus related to pancreatic cancer metabolism: A bibliometric and visualized analysis

BackgroundAs a malignant digestive system tumor, pancreatic cancer has unique metabolic characteristics. In recent years, the study of pancreatic cancer metabolism is in full swing, which provides a new direction for the treatment of pancreatic cancer patients. However, there is no systematic report of pancreatic cancer metabolism. In this paper, bibliometrics and visualization methods were used to analyze the number of publications, countries/regions, authors, institutions, journals, co-cited references, and keywords of pancreatic cancer metabolism articles, to summarize the research trends and predict research hotspots. MethodsWe searched, screened and downloaded articles on pancreatic cancer metabolism through the Web of Science Core Collection (WoSCC). Using CiteSpace, VOSviewer and Bibliometrix Package to analyze publications, countries/regions, authors, institutions, journals, co-cited references, and keywords of pancreatic cancer metabolism to identify research trends and predict research hotspots. ResultsAccording to the inclusion and exclusion criteria, a total of 5,255 articles were retrieved during the period 1943-2022. The number of publications on pancreatic cancer metabolism is increasing year by year. The United States (n=1602, 30.49%), China (n=1074, 20.44%), and Italy (n=313, 5.96%) are the three countries with the largest number of publications and citations, and there is close cooperation between countries. LI J (n=55) is the most prolific author. FUDAN UNIV (n=348) is the most published institution. CANCERS (n=118), PLOS ONE (n=93), and CANCER RESEARCH (n=80) are the most popular journals in this field. Nutriment-deficient environment, cancer chemoprevention and targeting cancer stem cell are the main areas of focus. immunotherapy, ferroptosis and targeted therapy are hot keywords in recent years. Taking pancreatic cancer metabolism as an entry point to study the role of traditional Chinese medicine (TCM) mainly focuses on curcumin and resveratrol, lack of broader and deeper research on TCM. ConclusionsThe number of publications on pancreatic cancer metabolism has generally increased, and scholars have generally paid more attention to this field. immunotherapy, ferroptosis and targeted therapy are the current research hotspots. The in-depth study of pancreatic cancer metabolism will provide new ideas for the treatment of pancreatic cancer.

Automated summary

Pancreatic cancer metabolism, as a research field, has attracted increasing attention in recent years. The number of publications on this topic has been continuously increasing. The United States, China, and Italy are the top three countries with the highest number of publications, showing close collaboration among researchers worldwide. The main research areas in this field include nutriment-deficient environment, cancer chemoprevention, and targeting cancer stem cells. Immunotherapy, ferroptosis, and targeted therapy are identified as hot keywords in recent years.