4.6 Article

Assessment of tuberculosis disease activity in people infected with Mycobacterium tuberculosis and living with HIV: A longitudinal cohort study

Journal

ECLINICALMEDICINE
Volume 49, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.eclinm.2022.101470

Keywords

Incipient tuberculosis; Tuberculosis; Biomarker; HIV

Funding

  1. Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-11-2-0174, W81XWH18-2-0040]
  2. U.S. Department of Defense [W81XWH-11-2-0174, W81XWH18-2-0040]
  3. Bundesministerium fur Bildung und Forschung (BmBF) through Deutsches Zentrum fur Infektionsforschung (DZIF, TTU-TB personalized medicine) [TTU 02_813]

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This study assessed TB disease activity in HIV-infected individuals co-infected with MTB and found that MTB-specific T-cell activation can differentiate active TB from latent TB and can also be detected in incipient TB cases. The findings suggest that blood biomarkers, such as MTB-specific T-cell activation, can aid in the early detection of TB and improve clinical outcomes by reducing transmission.
Background Early detection of asymptomatic incipient tuberculosis (TB) could improve clinical outcomes and reduce the spread of Mycobacterium tuberculosis (MTB) infection, particularly in HIV endemic settings. This study assessed TB disease activity over 5 years in people living with HIV co-infected with MTB using a surrogate biomarker. Methods Between Jan 1, 2013 and Aug 31, 2018, 2014 people living with HIV were screened annually for active TB using the Xpert MTB/RIF diagnostic assay in 11 clinics in Kenya, Tanzania, Uganda, and Nigeria. Longitudinal blood mononuclear cell samples from 46 selected patients with active and recurrent tuberculosis, latent infection, or incipient TB were further analysed for MTB-specific T-cell activation (defined by CD38 expression) as a well-defined surrogate marker for TB disease covering a total of 1758 person-months. Findings MTB-specific CD4 T-cell activation differentiated active, Xpert MTB/RIF positive TB from latent TB with a sensitivity and specificity of 86% and was reduced upon TB treatment initiation. Activated MTB-specific T cells were present in 63% and 23% of incipient TB cases 6 and 12 months before diagnosis of active disease, respectively. Transient increases of MTB-specific T cell activation were also observed in individuals with latent infection, while persistent activation was a hallmark of recurrent TB after the end of treatment. Interpretation In most cases, progression to active TB disease started 6-12 months before diagnosis by clinical symptoms and sputum occurrence of bacilli. Blood biomarkers could facilitate early detection of incipient TB, improve clinical outcomes, and reduce the transmission of MTB.

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