Acute lymphoblastic leukemia masquerading as hemophagocytic lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH) is a condition characterized by immunological imbalance due to inappropriate activation of macrophage, T/NK cells resulting in hypercytokinemia and subsequent tissue damage. We present an interesting case of acute lymphoblastic leukemia (ALL) who presented to us with clinical and laboratory features of HLH. High index of suspicion for malignancy based on clinical history and bone marrow examination led us to reach at definitive diagnosis of ALL.

Automated summary

This article presents an interesting case of HLH in a patient with acute lymphoblastic leukemia. The definitive diagnosis of ALL was reached based on clinical history and bone marrow examination.