4.0 Review

Structure-activity features of purines and their receptors: implications in cell physiopathology

Related references

Note: Only part of the references are listed.
Article Medicine, General & Internal

Hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global health challenge with rising incidence projected to exceed 1 million cases by 2025. Infection by hepatitis B and C viruses remains a major risk factor for HCC, while non-alcoholic steatohepatitis is emerging as a more common risk factor in Western countries. Advances in systemic therapies for HCC, including immunotherapies and targeted therapies, are expected to revolutionize the management of this disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

Review Pharmacology & Pharmacy

P2X receptors in cancer growth and progression

Francesco Di Virgilio et al.

Summary: Ion channels, especially P2X receptors, play crucial roles in tumor development, closely related to extracellular ATP, and could be key regulators of tumor growth.

BIOCHEMICAL PHARMACOLOGY (2021)

Review Biochemistry & Molecular Biology

Autocrine and paracrine purinergic signaling in the most lethal types of cancer

M. Reyna-Jeldes et al.

Summary: Cancer is characterized by abnormal and uncontrolled cell growth, leading to tumor formation. Purinergic signaling, with changes in receptors and nucleotide metabolism in tumor cells, could serve as a potential biomarker or therapeutic target for the ten most lethal cancers.

PURINERGIC SIGNALLING (2021)

Article Pharmacology & Pharmacy

Purinergic P2Y2 and P2X4 Receptors Are Involved in the Epithelial-Mesenchymal Transition and Metastatic Potential of Gastric Cancer Derived Cell Lines

Mauricio Reyna-Jeldes et al.

Summary: The study investigated the role of purinergic signaling in gastric cancer, revealing that the expression patterns of P2Y2R and P2X4R in GC cells are associated with cell proliferation, migration, and epithelial-mesenchymal transition (EMT).

PHARMACEUTICS (2021)

Review Oncology

Extracellular ATP and Adenosine in Cancer Pathogenesis and Treatment

Anna M. Chiarella et al.

Summary: ATP hydrolysis and downstream signaling pathways play a crucial role in tumor progression and metastasis in the extracellular space. The complexity and interdependence of various cell types in the extracellular space are increasingly recognized, leading to attention on therapeutic strategies targeting extracellular adenosine metabolism and signaling in the development and progression of malignancies. This review provides a summary of the molecular and physiological roles of extracellular ATP and adenosine in normal and disease states, as well as their potential therapeutic applications.

TRENDS IN CANCER (2021)

Article Biochemistry & Molecular Biology

Adenosine inhibits human astrocyte proliferation independently of adenosine receptor activation

Helena Marcelino et al.

JOURNAL OF NEUROCHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Tautomerism of Guanine Analogues

Jakub Radek Stocek et al.

BIOMOLECULES (2020)

Article Biochemistry & Molecular Biology

P2X7 receptor activity landscape in rat and human glioma cell lines

Damian Matysniak et al.

ACTA BIOCHIMICA POLONICA (2020)

Review Biochemistry & Molecular Biology

On the epigenetic role of guanosine oxidation

Marco Giorgio et al.

REDOX BIOLOGY (2020)

Review Cell Biology

Purinergic Signaling in the Hallmarks of Cancer

Anai del Rocio Campos-Contreras et al.

CELLS (2020)

Review Oncology

The adenosine pathway in immuno-oncology

Bertrand Allard et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Review Urology & Nephrology

Conversion of extracellular ATP into adenosine: a master switch in renal health and disease

Karen M. Dwyer et al.

NATURE REVIEWS NEPHROLOGY (2020)

Review Cell Biology

Extracellular ATP: A Feasible Target for Cancer Therapy

Valentina Vultaggio-Poma et al.

CELLS (2020)

Article Chemistry, Medicinal

Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compounds

Hiroyuki Tobinaga et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)

Review Pharmacology & Pharmacy

Recent Advances of In-Silico Modeling of Potent Antagonists for the Adenosine Receptors

Pabitra Narayan Samanta et al.

CURRENT PHARMACEUTICAL DESIGN (2019)

Review Pharmacology & Pharmacy

Molecular Dynamics Simulations of Adenosine Receptors: Advances, Applications and Trends

Nizar A. Al-Shar'i et al.

CURRENT PHARMACEUTICAL DESIGN (2019)

Review Biology

The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression

Peter Vaupel et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2019)

Editorial Material Pharmacology & Pharmacy

Recent Updates in the Computer Aided Drug Design Strategies for the Discovery of Agonists and Antagonists of Adenosine Receptors

Pran Kishore Deb

CURRENT PHARMACEUTICAL DESIGN (2019)

Article Neurosciences

An Allosteric Inhibitory Site Conserved in the Ectodomain of P2X Receptor Channels

Ariel R. Ase et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

Review Pharmacology & Pharmacy

The Purinergic System as a Pharmacological Target for the Treatment of Immune-Mediated Inflammatory Diseases

Luca Antonioli et al.

PHARMACOLOGICAL REVIEWS (2019)

Review Chemistry, Medicinal

Recent progress on the discovery of P2Y14 receptor antagonists

Ran Lu et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Gastroenterology & Hepatology

A global view of hepatocellular carcinoma: trends, risk, prevention and management

Ju Dong Yang et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Review Biochemistry & Molecular Biology

Purinergic signaling in hepatic disease

E. Velazquez-Miranda et al.

PURINERGIC SIGNALLING (2019)

Review Gastroenterology & Hepatology

Methionine adenosyltransferases in liver cancer

Ben Murray et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

Review Biochemistry & Molecular Biology

A2B Adenosine Receptor and Cancer

Zhan-Guo Gao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Expression of Adenosine Receptors in Rodent Pancreas

Mikio Hayashi

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Oncology

Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells

Beatris Mastelic-Gavillet et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

Review Neurosciences

Purinergic receptors in neurogenic processes

D. E. Ribeiro et al.

BRAIN RESEARCH BULLETIN (2019)

Article Immunology

Extracellular nucleotides and nucleosides as signalling molecules

Anna Lisa Giuliani et al.

IMMUNOLOGY LETTERS (2019)

Article Clinical Neurology

Adenosine heteroreceptor complexes in the basal ganglia are implicated in Parkinson's disease and its treatment

Dasiel O. Borroto-Escuela et al.

JOURNAL OF NEURAL TRANSMISSION (2019)

Article Multidisciplinary Sciences

Participation of the adenosine salvage pathway and cyclic AMP modulation in oocyte energy metabolism

Dulama Richani et al.

SCIENTIFIC REPORTS (2019)

Article Medicine, General & Internal

Adenosine Attenuates Aortic Smooth Muscle Cell Calcification through A3 Adenosine Receptor

Kenta Fujimoto et al.

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Article Medicine, Research & Experimental

3-methyadenine attenuates chloroform-induced hepatotoxicity via autophagy activation

Lei Wang et al.

BIOMEDICAL RESEARCH-TOKYO (2018)

Review Oncology

Targeting Autophagy in Cancer

Angelique V. Onorati et al.

CANCER (2018)

Review Physiology

PHARMACOLOGY OF ADENOSINE RECEPTORS: THE STATE OF THE ART

Pier Andrea Borea et al.

PHYSIOLOGICAL REVIEWS (2018)

Review Gastroenterology & Hepatology

Deregulation of methionine metabolism as determinant of progression and prognosis of hepatocellular carcinoma

Rosa M. Pascale et al.

TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY (2018)

Review Chemistry, Medicinal

Structure-Based Rational Design of Adenosine Receptor Ligands

Hugo Gutierrez-de-Teran et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2017)

Review Biochemistry & Molecular Biology

Extracellular ATP and adenosine: The Yin and Yang in immune responses?

M. M. Faas et al.

MOLECULAR ASPECTS OF MEDICINE (2017)

Review Cell Biology

P2Y12 receptor gene mutations associated with bleeding

Mariangela Scavone et al.

PLATELETS (2017)

Review Oncology

Targeting immunosuppressive adenosine in cancer

D. Vijayan et al.

NATURE REVIEWS CANCER (2017)

Article Pharmacology & Pharmacy

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors

Stephen P. H. Alexander et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Review Neurosciences

Medicinal chemistry of adenosine, P2Y and P2X receptors

Kenneth A. Jacobson et al.

NEUROPHARMACOLOGY (2016)

Article Physiology

The adenosine A2B receptor is involved in anion secretion in human pancreatic duct Capan-1 epithelial cells

M. Hayashi et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2016)

Review Oncology

Molecular Pathogenesis of Hepatocellular Carcinoma

Daniel Wai-Hung Ho et al.

LIVER CANCER (2016)

Article Chemistry, Medicinal

New antitumor 6-chloropurine nucleosides inducing apoptosis and G2/M cell cycle arrest

Stefan Schwarz et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Chemistry, Medicinal

Synthesis of novel substituted purine derivatives and identification of the cell death mechanism

Zeynep Demir et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Chemistry, Multidisciplinary

N7 Methylation Alters Hydrogen-Bonding Patterns of Guanine in Duplex DNA

Yi Kou et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Article Multidisciplinary Sciences

Two disparate ligand-binding sites in the human P2Y1 receptor

Dandan Zhang et al.

NATURE (2015)

Review Biochemistry & Molecular Biology

John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y Receptors

Kenneth A. Jacobson et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2015)

Review Pharmacology & Pharmacy

Nucleotides Acting at P2Y Receptors: Connecting Structure and Function

Kenneth A. Jacobson et al.

MOLECULAR PHARMACOLOGY (2015)

Review Chemistry, Multidisciplinary

Geometric and energetic consequences of prototropy for adenine and its structural models - a review

Ewa D. Raczynska et al.

RSC ADVANCES (2015)

Review Physiology

Purinergic signalling: from discovery to current developments

Geoffrey Burnstock

EXPERIMENTAL PHYSIOLOGY (2014)

Article Multidisciplinary Sciences

Agonist-bound structure of the human P2Y12 receptor

Jin Zhang et al.

NATURE (2014)

Article Multidisciplinary Sciences

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

Kaihua Zhang et al.

NATURE (2014)

Review Biochemistry & Molecular Biology

Nucleoside transporters in the purinome

Alexandre dos Santos-Rodrigues et al.

NEUROCHEMISTRY INTERNATIONAL (2014)

Article Biochemistry & Molecular Biology

NTPDase3 and ecto-5'-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression

Liliana Rockenbach et al.

PURINERGIC SIGNALLING (2014)

Review Biotechnology & Applied Microbiology

Adenosine receptors as drug targets - what are the challenges?

Jiang-Fan Chen et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Review Biochemistry & Molecular Biology

Purinergic signalling and cancer

Geoffrey Burnstock et al.

PURINERGIC SIGNALLING (2013)

Article Genetics & Heredity

Guanine Holes Are Prominent Targets for Mutation in Cancer and Inherited Disease

Albino Bacolla et al.

PLOS GENETICS (2013)

Review Gastroenterology & Hepatology

S-adenosylmethionine metabolism and liver disease

Jose M. Mato et al.

ANNALS OF HEPATOLOGY (2013)

Review Oncology

Immunity, inflammation and cancer: a leading role for adenosine

Luca Antonioli et al.

NATURE REVIEWS CANCER (2013)

Article Pathology

Autophagy as a Stress-Response and Quality-Control Mechanism: Implications for Cell Injury and Human Disease

Lyndsay Murrow et al.

Annual Review of Pathology-Mechanisms of Disease (2012)

Article Biochemistry & Molecular Biology

Involvement of P2X4 receptor in P2X7 receptor-dependent cell death of mouse macrophages

Ayumi Kawano et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

Review Oncology

Purines, Purinergic Receptors, and Cancer

Francesco Di Virgilio

CANCER RESEARCH (2012)

Review Gastroenterology & Hepatology

Genetic profiling of intrahepatic cholangiocarcinoma

Jesper B. Andersen et al.

CURRENT OPINION IN GASTROENTEROLOGY (2012)

Article Chemistry, Medicinal

Adenosiland: Walking through adenosine receptors landscape

Matteo Floris et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)

Article Chemistry, Organic

Effect of the H-Bonding on Aromaticity of Purine Tautomers

Olga A. Stasyuk et al.

JOURNAL OF ORGANIC CHEMISTRY (2012)

Review Physiology

S-ADENOSYLMETHIONINE IN LIVER HEALTH, INJURY, AND CANCER

Shelly C. Lu et al.

PHYSIOLOGICAL REVIEWS (2012)

Article Biochemistry & Molecular Biology

P2X7 receptor activation leads to increased cell death in a radiosensitive human glioma cell line

Marina Petersen Gehring et al.

PURINERGIC SIGNALLING (2012)

Article Pharmacology & Pharmacy

P2X4 receptors interact with both P2X2 and P2X7 receptors in the form of homotrimers

L. S. Antonio et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

Article Multidisciplinary Sciences

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

Guillaume Lebon et al.

NATURE (2011)

Review Physiology

Signalling and pharmacological properties of the P2Y14 receptor

T. K. Harden et al.

ACTA PHYSIOLOGICA (2010)

Article Gastroenterology & Hepatology

Analysis of the liver mitochondrial proteome in response to ethanol and S-adenosylmethionine treatments: novel molecular targets of disease and hepatoprotection

Kelly K. Andringa et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)

Review Physiology

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

Brinda Ravikumar et al.

PHYSIOLOGICAL REVIEWS (2010)

Article Oncology

Differential ectonucleotidase expression in human bladder cancer cell lines

Joseli Stella et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2010)

Article Oncology

Selective NTPDase2 expression modulates in vivo rat glioma growth

Elizandra Braganhol et al.

CANCER SCIENCE (2009)

Article Endocrinology & Metabolism

Inhibition of Ca2+ signaling and glucagon secretion in mouse pancreatic α-cells by extracellular ATP and purinergic receptors

Eva Tuduri et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2008)

Article Cell Biology

The role of ecto-5′-nucleotidase/CD73 in glioma cell line proliferation

Luci Bavaresco et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2008)

Article Neurosciences

P2X7 Receptors in Oligodendrocytes: A Novel Target for Neuroprotection

Carlos Matute

MOLECULAR NEUROBIOLOGY (2008)

Article Oncology

Host A2B adenosine receptors promote carcinoma growth

Sergey Ryzhov et al.

NEOPLASIA (2008)

Review Gastroenterology & Hepatology

Role of S-adenosyl-L-methionine in liver health and injury

Jose M. Mato et al.

HEPATOLOGY (2007)

Article Chemistry, Medicinal

3D-pharmacophore models for selective A2A and A2B adenosine receptor antagonists

Jing Wei et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2007)

Review Physiology

Physiology and pathophysiology of purinergic neurotransmission

Geoffrey Burnstock

PHYSIOLOGICAL REVIEWS (2007)

Article Oncology

Increased resistance of glioma cell lines to extracellular ATP cytotoxicity

FB Morrone et al.

JOURNAL OF NEURO-ONCOLOGY (2005)

Article Spectroscopy

Electronic transitions of guanine tautomers, their stacked dimers, trimers and sodium complexes

PS Kushwaha et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2004)

Review Hematology

Purinergic signaling and vascular cell proliferation and death

G Burnstock

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2002)

Review Pharmacology & Pharmacy

Adenosine receptors and their ligands

KN Klotz

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2000)