Journal
MEDICINE
Volume 101, Issue 45, Pages -Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MD.0000000000031705
Keywords
BRCA2; breast cancer; ovarian cancer; PRAP inhibitor; prostate cancer
Categories
Funding
- National Natural Science Foundation of China [81870683, 82121003]
- Department of Science and Technology of Sichuan Province [2020JDTD0028, 2022YFS0606, 22ZYZYTS0151]
- CAMS Innovation Fund for Medical Sciences [2019-12M-5-032]
Ask authors/readers for more resources
Breast cancer susceptibility gene 2 (BRCA2) is the main gene associated with hereditary breast cancers, but mutations in BRCA2 are also found in other types of tumors. This review discusses the biological functions of BRCA2 and the role of BRCA2 mutations in tumor progression and therapy.
Breast cancer susceptibility gene 2 (BRCA2) is the main gene associated with hereditary breast cancers. However, a mutation in BRCA2 has also been found in other tumors, such as ovarian, pancreatic, thyroid, gastric, laryngeal, and prostate cancers. In this review, we discuss the biological functions of BRCA2 and the role of BRCA2 mutations in tumor progression and therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
