Journal
GELS
Volume 8, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/gels8120773
Keywords
smart; temporary film; microgels; controllable drug release; local delivery system
Categories
Funding
- National Natural Science Foundation of China
- Jiangxi Provincial Natural Science Foundation
- Jiangxi Provincial high-level and urgently needed overseas talent introduction plan
- Science and Technology Research Project of the Jiangxi Education Department
- [32260238]
- [20202BABL214018]
- [20212BAB204004]
- [20212ACB214002]
- [20212BCJ25021]
- [GJJ200665]
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A smart temporary film was prepared from doxorubicin-loaded shape-memory microgels in this study, which exhibited controllable drug-release behavior and showed advantages in weaker cytotoxicity, longer antitumor capability, and higher drug-utilization efficiency.
The development of a simple local drug-delivery system that exhibits the advantages of macro- and microscale carriers with controllable drug-release behavior is still highly desired. Herein, in this work, a smart temporary film was prepared from doxorubicin (DOX)-loaded shape-memory microgels via a simple hot-compression programming method. The temporary film showed a very smooth surface and easy handing, as well as macroscopy mechanical properties, which could disintegrate into the microgels with heating at 45 degrees C. In this case, the temporary film showed a controllable DOX release behavior when compared with the microgels, which could release the DOX on demand. Consequently, the temporary film exhibited weaker cytotoxicity to normal cells and a much longer antitumor capability, as well as a higher drug-utilization efficiency when compared with microgels. Therefore, the smart temporary film has high potential as a candidate for use as a local drug-delivery system.
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