Journal
CANCER IMMUNOLOGY RESEARCH
Volume 4, Issue 9, Pages 721-725Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2326-6066.CIR-16-0193
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NCI NIH HHS [P30 CA008748] Funding Source: Medline
- NIAID NIH HHS [R37 AI034206] Funding Source: Medline
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The immune system of vertebrate animals has evolved to mount an effective defense against a diverse set of pathogens while minimizing transient or lasting impairment in tissue function that could result from the inflammation caused by immune responses to infectious agents. In addition, misguided immune responses to self and dietary antigens, as well as to commensal microorganisms, can lead to a variety of inflammatory disorders, including autoimmunity, metabolic syndrome, allergies, and cancer. Regulatory T cells expressing the X chromosome-linked transcription factor Foxp3 suppress inflammatory responses in diverse biological settings and serve as a vital mechanism of negative regulation of immune-mediated inflammation. (C) 2016 AACR.
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