Journal
FRONTIERS IN IMMUNOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.1038650
Keywords
pancreatic cancer; tumour microenvironment; glucose metabolism; treatment; prognosis
Categories
Funding
- National Natural Science Foundation of China
- Natural Science Foundation of Gansu Province
- Traditional Chinese Medicine Scientific Research Project of Gansu Province, China
- [82260555]
- [21JR1RA102]
- [GZKP-2020-28]
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Metabolic reprogramming and the relationship between glucose metabolism and tumor microenvironment play a crucial role in pancreatic cancer. This study sheds light on the development of new therapies targeting the metabolism of cancer cells.
Early and accurate diagnosis and treatment of pancreatic cancer (PC) remain challenging endeavors globally. Late diagnosis lag, high invasiveness, chemical resistance, and poor prognosis are unresolved issues of PC. The concept of metabolic reprogramming is a hallmark of cancer cells. Increasing evidence shows that PC cells alter metabolic processes such as glucose, amino acids, and lipids metabolism and require continuous nutrition for survival, proliferation, and invasion. Glucose metabolism, in particular, regulates the tumour microenvironment (TME). Furthermore, the link between glucose metabolism and TME also plays an important role in the targeted therapy, chemoresistance, radiotherapy ineffectiveness, and immunosuppression of PC. Altered metabolism with the TME has emerged as a key mechanism regulating PC progression. This review shed light on the relationship between TME, glucose metabolism, and various aspects of PC. The findings of this study provide a new direction in the development of PC therapy targeting the metabolism of cancer cells.
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