In silico testing of the universality of epithelial tissue growth

The universality of interfacial roughness in growing epithelial tissue has remained a controversial issue. Kardar-Parisi-Zhang (KPZ) and molecular beam epitaxy (MBE) universality classes have been reported among other behaviors including a total lack of universality. Here, we simulate tissues using the CELLSIM3D kinetic division model for deformable cells to investigate cell-colony scaling. With seemingly minor model changes, it can reproduce both KPZ- and MBE-like scaling in configurations that mimic the respective experiments. Tissue growth with strong cell-cell adhesion in a linear geometry is KPZ like, while weakly adhesive tissues in a radial geometry are MBE like. This result neutralizes the apparent scaling controversy.

Automated summary

The universality of interfacial roughness in growing epithelial tissue has been a controversial issue. However, using a simulation model, it is found that the geometric shape of the tissue and the strength of cell-cell adhesion determine the scaling behavior, resolving the controversy.