Journal
PHYSICAL REVIEW E
Volume 106, Issue 6, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevE.106.L062402
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Funding
- Natural Sciences and Engineering Research Council of Canada
- Canada Research Chairs Programs
- Western University's Science International Engagement Fund
- Academy of Finland [304973]
- Academy of Finland (AKA) [304973] Funding Source: Academy of Finland (AKA)
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The universality of interfacial roughness in growing epithelial tissue has been a controversial issue. However, using a simulation model, it is found that the geometric shape of the tissue and the strength of cell-cell adhesion determine the scaling behavior, resolving the controversy.
The universality of interfacial roughness in growing epithelial tissue has remained a controversial issue. Kardar-Parisi-Zhang (KPZ) and molecular beam epitaxy (MBE) universality classes have been reported among other behaviors including a total lack of universality. Here, we simulate tissues using the CELLSIM3D kinetic division model for deformable cells to investigate cell-colony scaling. With seemingly minor model changes, it can reproduce both KPZ- and MBE-like scaling in configurations that mimic the respective experiments. Tissue growth with strong cell-cell adhesion in a linear geometry is KPZ like, while weakly adhesive tissues in a radial geometry are MBE like. This result neutralizes the apparent scaling controversy.
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